Table 1 Baseline characteristics and outcomes by urine YKL-40 value
From: Urine YKL-40 is associated with progressive acute kidney injury or death in hospitalized patients
Urine YKL-40 | ||||
|---|---|---|---|---|
Characteristic 1 | All (N = 249) | <5 ng/ml (N = 218) | ≥5 ng/ml (N = 31) | P-value 2 |
Demographics | ||||
Age ≥65 years | 143 (57) | 121 (56) | 22 (71) | 0.10 |
Male sex | 143 (57) | 125 (57) | 18 (58) | 0.94 |
Non-White race | 59 (24) | 52 (24) | 7 (23) | 0.88 |
Body Mass Index, kg/m2 | 29.9 ± 8 | 30 ± 8 | 27 ± 6 | 0.06 |
Clinical Characteristics | ||||
Pre-existing CKD | 62 (25) | 54 (25) | 8 (27) | 0.87 |
Pre-existing proteinuria | 63 (32) | 49 (29) | 14 (50) | 0.03 |
ACEi/ARB at enrollment | 88 (36) | 78 (37) | 10 (34) | 0.82 |
Hypertension | 171 (69) | 147 (68) | 24 (77) | 0.28 |
Diabetes | 102 (41) | 88 (41) | 14 (45) | 0.64 |
CHF | 92 (37) | 83 (39) | 9 (29) | 0.30 |
CAD | 102 (41) | 88 (41) | 14 (47) | 0.52 |
Stroke | 34 (14) | 26 (12) | 8 (26) | 0.04 |
Liver failure/Cirrhosis | 27 (11) | 24 (11) | 3 (10) | 0.82 |
Active cancer | 60 (24) | 46 (21) | 14 (45) | 0.004 |
# of Comorbidities | 0.31 | |||
None | 17 (7) | 16 (8) | 1 (3) | |
1 | 34 (14) | 31 (15) | 2 (7) | |
≥2 | 198 (79) | 160 (77) | 26 (90) | |
Tobacco use | 0.10 | |||
Never | 130 (52) | 118 (58) | 12 (43) | |
Prior | 60 (24) | 48 (24) | 12 (43) | |
Current | 42 (17) | 38 (19) | 4 (14) | |
Enrollment location | 0.12 | |||
ICU | 120 (48) | 101 (46) | 19 (61) | |
Floor | 129 (52) | 117 (54) | 12 (39) | |
Renal Function | ||||
Baseline SCr, mg/dl | 1.2 ± 0.5 | 1.2 ± 0.5 | 1.2 ± 0.5 | 0.44 |
Baseline GFR3 | 68.5 ± 30 | 68 ± 30 | 72 ± 28 | 0.49 |
Stage of AKI at enrollment | 0.001 | |||
Stage 1 | 207 (83) | 188 (86) | 19 (61) | |
Stage 2 | 42 (17) | 30 (14) | 12 (39) | |
Stage of AKI at peak SCr | 0.006 | |||
Stage 1 | 176 (71) | 162 (74) | 14 (45) | |
Stage 2 | 41 (16) | 33 (15) | 8 (26) | |
Stage 3 | 18 (7) | 13 (6) | 5 (16) | |
Stage 3-Dialysis4 | 14 (6) | 10 (5) | 4 (13) | |
AKI type | ||||
ATN | 51 (20) | 40 (18) | 11 (35) | 0.03 |
Pre-renal | 164 (66) | 151 (69) | 13 (42) | 0.003 |
Other | 34 (14) | 27 (12) | 7 (23) | 0.12 |
Discharge SCr, mg/dL | 1.4 ± 0.7 | 1.4 ± 0.7 | 1.3 ± 0.5 | 0.34 |