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Table 4 Relationship of estimated Net Acid Excretion with Albuminuria, Kidney Dysfunction, and CKD Stages and Risk Groups in participants without hypertension and without diabetes (n = 6,772)

From: Dietary acid load and chronic kidney disease among adults in the United States

Parameter

UACR+$ > 30 mg/g

eGFR$ < 60 ml/min/1.73m2

Stages of CKD#,**

Risk groups of CKD@**

OR (95% CI)

OR (95% CI)

OR (95% CI)

OR (95% CI)

Unadjusted

    

Quintile 1

Reference

Reference

Reference

Reference

Quintile 2

1.12 (0.77, 1.64)

1.26 (0.93, 1.69)

1.57 (1.11–2.22)

0.96 (0.75–1.23)

Quintile 3

1.62 (1.09, 2.39)

1.79 (1.23, 2.59)

1.88 (1.22–2.90)

1.64 (1.34–2.01)

Quintile 4

1.57 (1.16, 2.14)

2.09 (1.46, 2.99)

3.29 (2.06–5.27)

1.93 (1.51–2.46)

Quintile 5

1.79 (1.21, 2.65)

2.52 (1.80, 3.52)

3.51 (1.94–6.36)

2.99 (2.29–3.88)

ptrend

0.04

<0.0001

<0.0001

<0.0001

Adjusted*

    

Quintile 1

Reference

Reference

Reference

Reference

Quintile 2

0.96 (0.58–1.58)

0.82 (0.44–1.51)

1.26 (0.66–2.40)

0.77 (0.55–1.06)

Quintile 3

1.23 (0.80–1.88)

0.85 (0.58–1.25)

1.27 (0.70–2.31)

1.03 (0.77–1.37)

Quintile 4

1.09 (0.72–1.63)

1.07 (0.78–1.45)

1.13 (0.72–1.78)

0.90 (0.63–1.28)

Quintile 5

1.58 (1.04–2.39)

1.42 (1.07–2.10)

1.41 (0.92–2.16)

1.12 (0.75–1.67)

ptrend

0.05

0.01

0.06

0.07

  1. Quintile 1: min to 37.35 mEq/day; Quintile 2: >37.35 to 49.62 mEq/day; Quintile 3: >49.62 to 60.89 mEq/day; Quintile 4: >60.89 to 75.65 mEq/day; Quintile 5: >75.65 to max mEq/day.
  2. +UACR- urinary albumin to creatinine ratio.
  3. #CKD Stages defined by KDOQI Classification.
  4. @CKD Risk Groups defined by KDIGO Nomenclature.
  5. *Adjustment for demographics (age, gender and race/ethnicity), socio-economic status (education, poverty income ratio), body mass index, and risk factors (smoking, diabetes, hypertension, self-reported cardio-vascular diseases [CVD i.e. (coronary heart disease, congestive heart failure or stroke)]), total caloric intake, and body mass index.
  6. OR (95% CI) = Odds Ratio (95% confidence interval).
  7. $From multiple logistic regression.
  8. **From ordinal logistic regression.