Figure 5

Representative immunohistochemical staining profiles of expression of ICAM-1 and MCP-1 at 24 h and the results of semi-quantitative analyses. Ischemia–reperfusion (A and D) caused significant expression of ICAM-1 and MCP-1 in renal tubules and the cortical peritubular interstitium (B and E). Atorvastatin (IR + ATO) reduced this expression (C and F). Magnification, ×400 in A–F. Expression of ICAM-1 and MCP-1 after ischemia–reperfusion was increased (one-way ANOVA test; *p < 0.05, compared with the sham group; n = 8) and decreased after administration of ATO (**p < 0.05, compared with the IR group; n = 8).