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Table 2 Blood and urine biochemical examinations at 12 weeks

From: Effects of iodinated contrast agents on renal oxygenation level determined by blood oxygenation level dependent magnetic resonance imaging in rabbit models of type 1 and type 2 diabetic nephropathy

 

Control group

Type 1 DN group

Type 2 DN group

Kidney weight (g)

9.6 ± 1.42

10.07 ± 2.29*

10.51 ± 2.38*

Blood glucose (mmol/L)

4.77 ± 1.13

23.37 ± 6.72*

22.66 ± 5.00*

SCr (μmol/L)

56.24 ± 11.53

169.00 ± 12.08*

155.20 ± 13.27*

BUN (mmol/L)

4.28 ± 0.53

9.82 ± 0.76*

9.88 ± 0.69*

Urinary microalbumin (mg/L)

6.51 ± 1.38

21.71 ± 3.72*

21.39 ± 3.17*

Fasting insulin (μIU/mL)

7.61 ± 2.31

1.25 ± 1.37*

32.65 ± 2.56*

GAD-Ab†

+

IAA†

+

  1. Abbreviations: DN diabetic nephropathy, SCr serum creatinine, BUN blood urea nitrogen, GAD-Ab glutamic acid decarboxylase autoantibody, IAA insulin autoantibody.
  2. Normal ranges: blood glucose, 3.61–6.11 mmol/L; SCr, 44–133 μmol/L; BUN, 3.2–7.1 mmol/L; urinary microalbumin, <10 mg/L; fasting insulin, 5.8–18.6 μIU/mL.
  3. Values are means ± standard deviation.
  4. *P < 0.05 vs. control group.
  5. There were no significant difference between types 1 and 2 diabetic nephropathy in terms of blood glucose, SCr, BUN, and urinary microalbumin results.
  6. †Positivity for GAD-Ab and IAA is indicative of type 1 diabetes.