Effects of iodinated contrast agents on renal oxygenation level determined by blood oxygenation level dependent magnetic resonance imaging in rabbit models of type 1 and type 2 diabetic nephropathy

Table 6 Pimonidazole staining scores for the renal cortex and outer medulla in rabbits injected with 400 mg I/mL of contrast agent

	CG	Type 2 DN PC	Type 2 DN at 1 h	Type 2 DN at 24 h	Type 2 DN at 48 h	Type 2 DN at 72 h
Cortex	0.13 ± 0.01	0.53 ± 0.05	1.35 ± 0.12*	2.17 ± 0.17*	1.93 ± 0.08*	1.77 ± 0.14*
Outer medulla	0.12 ± 0.01	0.51 ± 0.06	1.87 ± 0.13*	2.83 ± 0.11*	2.62 ± 0.12*	2.31 ± 0.09*

Abbreviations: CG control group, DN diabetic nephropathy, PC positive control.
The CG and type 2 DN PC group were injected with physiological saline.
Values are means ± standard deviation.
*P < 0.05 vs. the cortex.
Pimonidazole staining scores were significantly different between the cortex and outer medulla at 1–72 h after injecting 400 mg I/mL of contrast agent, but not in the CG or the type 2 DN PC group.