From: Assessing the agreement of biomarker data in the presence of left-censoring
Per cent censoring | True ρ | True ρ c | Method | Mean | Relative bias (%) | Empirical SD | Mean SE | The percentage of 95% confidence intervals that include true value of CCC |
---|---|---|---|---|---|---|---|---|
(25%, 25%) | 0.25 | 0.238 | 1. Delete the pair | 0.1405 | −40.97 | 0.1119 | 0.1087 | 85.2 |
2. Replace by LOD | 0.2072 | −12.94 | 0.1214 | 0.0856 | 91.0 | |||
3. Replace by 0.5 × LOD | 0.1863 | −21.72 | 0.1630 | 0.0848 | 88.2 | |||
4. Replace by c × LOD | 0.1951 | −18.03 | 0.1240 | 0.0851 | 89.0 | |||
5. ML | 0.2346 | −1.43 | 0.0944 | 0.0939 | 94.3 | |||
0.50 | 0.476 | 1. Delete the pair | 0.2966 | −37.69 | 0.1197 | 0.0999 | 61.5 | |
2. Replace by LOD | 0.4169 | −12.42 | 0.1569 | 0.0735 | 86.4 | |||
3. Replace by 0.5 × LOD | 0.3664 | −23.03 | 0.3516 | 0.0742 | 78.0 | |||
4. Replace by c × LOD | 0.3821 | −19.73 | 0.1541 | 0.0744 | 78.3 | |||
5. ML | 0.4701 | −1.24 | 0.0807 | 0.0780 | 93.6 | |||
0.75 | 0.714 | 1. Delete the pair | 0.5307 | −25.67 | 0.0886 | 0.0762 | 38.6 | |
2. Replace by LOD | 0.6582 | −7.82 | 0.0996 | 0.0497 | 85.1 | |||
3. Replace by 0.5 × LOD | 0.6140 | −14.01 | 0.1482 | 0.0519 | 71.5 | |||
4. Replace by c × LOD | 0.6140 | −14.01 | 0.1662 | 0.0521 | 72.1 | |||
5. ML | 0.7077 | −0.88 | 0.0525 | 0.0503 | 94.8 |