From: Assessing the agreement of biomarker data in the presence of left-censoring
Per cent censoring | True ρ | True ρ c | Method | Mean | Relative bias (%) | Empirical SD | Mean SE | The percentage of 95% confidence intervals that include true value of CCC |
---|---|---|---|---|---|---|---|---|
(40%, 25%) | 0.25 | 0.238 | 1. Delete the pair | 0.1334 | −43.95 | 0.1858 | 0.1652 | 88.1 |
2. Replace by LOD | 0.1908 | −19.83 | 0.1525 | 0.1150 | 84.3 | |||
3. Replace by 0.5 × LOD | 0.1796 | −24.54 | 0.1467 | 0.1155 | 80.2 | |||
4. Replace by c × LOD | 0.1780 | −25.22 | 0.1528 | 0.1152 | 81.8 | |||
5. ML | 0.2296 | −3.53 | 0.1395 | 0.1345 | 92.4 | |||
0.50 | 0.476 | 1. Delete the pair | 0.2735 | −42.54 | 0.1693 | 0.1516 | 76.9 | |
2. Replace by LOD | 0.3673 | −22.84 | 0.2110 | 0.1004 | 80.2 | |||
3. Replace by 0.5 × LOD | 0.3366 | −29.29 | 0.2771 | 0.1011 | 74.3 | |||
4. Replace by c × LOD | 0.3537 | −25.70 | 0.1788 | 0.1011 | 75.9 | |||
5. ML | 0.4617 | −3.00 | 0.1206 | 0.1135 | 93.2 | |||
0.75 | 0.714 | 1. Delete the pair | 0.4913 | −31.19 | 0.1373 | 0.1184 | 62.3 | |
2. Replace by LOD | 0.6022 | −15.66 | 0.1705 | 0.0696 | 78.7 | |||
3. Replace by 0.5 × LOD | 0.5706 | −20.08 | 0.2039 | 0.0710 | 74.7 | |||
4. Replace by c × LOD | 0.5689 | −20.32 | 0.2151 | 0.0713 | 74.1 | |||
5. ML | 0.7003 | −1.92 | 0.0805 | 0.0750 | 93.2 |