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Table 7 Concordance correlation coefficients (and 95% confidence intervals) for 3 processes using 5 methods based on IL-18* assay

From: Assessing the agreement of biomarker data in the presence of left-censoring

Processes

Method 1

Method 2

Method 3

Method 4

Method 5

Delete the pair

Replace by LOD

Replace by 0.5 × LOD

Replace by c× LOD

ML

A (Initial 48 hours: 4°C vs −80°C)

0.8801 (0.81, 0.95)

0.8228 (0.73, 0.91)

0.8228 (0.73, 0.91)

0.8228 (0.73, 0.91)

0.8314 (0.74, 0.92)

B (Initial 48 hours: 25°C vs −80°C)

0.7344 (0.56, 0.91)

0.6081 (0.43, 0.77)

0.6081 (0.43, 0.77)

0.6081 (0.43, 0.77)

0.6819 (0.51, 0.85)

C (Centrifuge vs No Centrifuge)

0.9886 (0.98, 1.00)

0.9896 (0.98, 1.00)

0.9896 (0.98, 1.00)

0.9896 (0.98, 1.00)

0.9876 (0.99, 1.00)

  1. *IL-18 (Interleukin 18).