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Table 1 Main clinical characteristics and biological data of the total population of the study and according to antivitamin K (VKA) therapy status

From: Dephosphorylated-uncarboxylated Matrix Gla protein concentration is predictive of vitamin K status and is correlated with vascular calcification in a cohort of hemodialysis patients

  Total population Non-treated with VKA Treated with VKA P (between treated and non-treated)
n 160 137 23  
Age (yr) 74 [63; 80] 74 [64; 81] 71 [59; 79] NS
Male gender (%) 44 43 52 NS
Body mass index (kg/m2) 25.4 [22.6; 30.2] 25.4 [22.6; 30.2] 27.3 [24.7; 33.3] NS
Dialysis vintage (month) 23 [11; 44] 22 [11; 48] 24 [13; 38] NS
Previous CVD (%) 65 64 74 NS
Hypertension (%) 87 85 100 0.046
Diabetes (%) 44 43 52 NS
Smoking habit (%) 21 21 22 NS
Calcium (mmol/L) 2.15 ± 0.16 2.16 ± 0.15 2.14 ± 0.20 NS
Phosphate (mg/dL) 4.6 [4.0; 6.0] 4.6 [4; 6] 5.1 [4.3; 5.7] NS
Albumin (g/L) 38 [36; 40] 38 [36; 40] 40 [38; 40] NS
CRP (mg/L) 5 [2; 13] 5 [2; 13] 4 [3; 9] NS
Intact PTH (pg/mL) 263 [126; 434] 251 [129; 423] 291 [125; 570] NS
25-OH vitamin D (ng/mL) 22 [12; 33] 22 [12; 33] 19 [13; 25] NS
b-ALP (μg/L) 16 [11; 23] 15 [10; 23] 19 [13; 29] NS
FGF-23 (RU/mL) 2911 [1039; 7413] 2733 [883; 7597] 3179 [2391; 6676] NS
Calcification score (maximum score is 24) 10 [5; 15] 10 [5; 15] 11 [6; 17] NS
dp-ucMGP (pmol/L) 2148 [1542; 3251] 1939 [1419; 2841] 5604 [3758; 7836] <0.0001
  1. Note: conversion factor for units: phosphorus in mg/dL to mmol/L, x0.3229. Data are expressed as mean ± standard deviation (SD) when distribution was normal and as median and interquartile range [percentile 25; percentile 75] when not. CVD, cardiovascular disease; CRP, C-reactive protein; PTH, parathormone; b-ALP bone-specific alkaline phosphatase; dp-ucMGP, dephosphorylated and uncarboxylated; NS, non significant (p > 0.05).