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Table 2 Multivariable adjusted associations between bolus versus maintenance (Referent) dosing and study outcome (N=48,050)

From: Comparative short-term safety of bolus versus maintenance iron dosing in hemodialysis patients: a replication study

Outcome Effect measure1 Estimate (95% CI)
  Death from any cause Hazard Ratio 0.92 (0.79, 1.06)
Rate Difference -16 (-42, 13)
Infection Outcomes   
  Hospitalized for pneumonia, sepsis, vascular access infection Hazard Ratio 1.08 (0.96, 1.21)
Rate Difference 21 (-9.2, 54)
  Hospitalized for infection of any major organ system Hazard Ratio 1.13 (1.03, 1.24)
Rate Difference 59 (19, 106)
  Use of intravenous antibiotics Hazard Ratio 1.08 (1.02, 1.15)
Rate Difference 72 (9.1, 135)
  Infection-Related Death Hazard Ratio 1.17 (0.80, 1.71)
Rate Difference 3.9 (-5.1, 14)
  Hospitalized for pneumonia, vascular access infection, sepsis or infection-related death Hazard Ratio 1.08 (0.96, 1.21)
Rate Difference 23 (-9.5, 56)
  Hospitalized for any infection or use of intravenous antibiotics Hazard Ratio 1.08 (1.02, 1.15)
Rate Difference 107 (28, 187)
Cardiovascular Outcomes   
  Hospitalized for stroke Hazard Ratio 1.07 (0.77, 1.47)
Rate Difference 1.7 (-10, 15)
  Hospitalized for Myocardial Infarction Hazard Ratio 0.95 (0.69, 1.32)
Rate Difference -1.7 (-13, 10)
  Cardiovascular-related death Hazard Ratio 0.82 (0.66, 1.02)
Rate Difference -14 (-31, 0.97)
  Cardiovascular-related hospitalization or death Hazard Ratio 0.92 (0.78, 1.09)
Rate Difference -11 (-35, 13)
  1. 1Rate difference per 1000 patient years.