Figure 2

Lung biopsy performed by computed tomography-guided needle biopsy and renal biopsy before treatment. (a) Multi-nucleated giant cells and inflammatory cells infiltrating necrotizing lesions are shown. (b) Granulomatous tubulointerstitial nephritis. Hematoxylin and eosin stain, ×40. (c) Focal segmental necrotizing glomerulonephritis (arrow). The glomerular podocytes were swollen and vacuolated. PASM stain, ×400. (d) Crescentic glomerulonephritis. Podocytes in the cellular crescent were not vacuolated. PASM stain, ×400. (e) Inclusion bodies were detected in the podocytes. Toluidine blue stain, ×400. (f) Podocytes containing osmiophilic inclusion bodies ("myeloid bodies") were revealed by electron microscopy (×2000).