Table 1 Baseline characteristics of the study sample, by presence of baseline CHD and GFR quartiles estimated by CKD-EPI equation (n = 789)

No CHD (n = 469)

Sex, n, M/F

164/305

41/76

42/77

40/76

41/76

1.00

eGFR,ml/min per 1.73 m²

74 ± 8.6

93.7 ± 4

104.2 ± 3.3

117.3 ± 6.8

Creatinine, mg/dl

0.947 ± 0.14

.763 ± 0.14

.642 ± 0.14

.534 ± 0.11

Age, yrs

59.7 ± 6.8

57.4 ± 7.4

54.6 ± 8

47.8 ± 6

<0.001

BMI, kg/m²

28 ± 4

27.8 ± 3.1

27.2 ± 4

27.1 ± 3.8

0.20

Systolic BP, mmHg

129.4 ± 20

126 ± 19

125.6 ± 20

123.8 ± 19

0.16

Diastolic BP, mmHg

79.3 ± 10.4

77.7 ± 12

78.4 ± 10.4

75.9 ± 9.7

0.10

Total cholest, mg/dl

448

214 ± 49

213.5 ± 48

212 ± 47

198 ± 43

0.042

LDL cholest, mg/dl

445

132 ± 39

130.5 ± 38

129 ± 39

112.5 ± 32.4

<0.001

HDL cholest, mg/dl

448

53.1 ± 13.5

53.2 ± 13.4

49.6 ± 14

47.6 ± 16

0.007

F.triglycerides, mg/dl

448

154 ± 72

157 ± 82

162 ± 97

195 ± 149

0.014

Fast glucose, mg/dl

467

110 ± 30

115 ± 52

117 ± 43

117 ± 34

0.51

HbA1c,%l

423

5.98 ± 0.8

5.95 ± 1.1

6.06 ± 1.1

5.91 ± 1.13

0.75

Uric acid, mg/dl

385

5.43 ± 1.1

5.2 ± 1.3

4.97 ± 1.2

4.79 ± 1.17

0.001

C-reactive protein,¶ mg/L

371

2.42 x2.74

2.64 x2.64

2.61 x2.61

2.38 x2.39

0.81

Current; past smokers,%

15.2; 29.8

22.6; 19.3

27.6; 17.5

34.8; 33.3

<0.001

LV ejection fraction,%

273

60.5 ± 7

60.1 ± 6

59.3 ± 5.7

57.2 ± 11

0.058

Diabetes baseline, n,%

22; 18.8

23; 19.3

30; 25.9

26; 22.2

0.54

CHD (n = 320)

Ren. fnct.

Mild dysfnct.

Normal

Normal

“Hyperfiltrator”

Sex, n, M/F

222/98

54/27

49/26

58/25

61/20

0.53

eGFR,ml/min per 1.73 m²

320

74.3 ± 8

93 ± 3.6

103.6 ± 3.6

115.3 ± 6

Creatinine, mg/dl

1.02 ± 0.15

0.81 ± 0.14.6

0.673 ± 0.14

0.589 ± 0.103

Age, yrs

320

59.6 ± 7

58.7 ± 7.3

57.5 ± 7.7

50.6 ± 6.6

<0.001

BMI, kg/m²

27.5 ± 3.9

28.3 ± 4

26.9 ± 3

27.6 ± 4.1

0.14

Systolic BP, mmHg

132.8 ± 18

134 ± 17

134 ± 16.5

132.3 ± 21

0.95

Diastolic BP, mmHg

81.3 ± 11

82.2 ± 9

80.6 ± 9.9

81 ± 9.5

0.78

Total cholest, mg/dl

315

191 ± 42

195 ± 42.5

187 ± 48

193 ± 39

0.73

LDL cholest, mg/dl

312

113 ± 32

118 ± 35

112.6 ± 36

116.9 ± 36

0.71

HDL cholest, mg/dl

315

43.7 ± 12

43.8 ± 11

42.3 ± 12

41 ± 9.6

0.36

F. triglycerides, mg/dl

315

168 ± 82

168 ± 86

164 ± 93

177 ± 100

0.85

Fast glucose, mg/dl

124 ± 58

124 ± 45

129 ± 52

129.6 ± 72

0.87

HbA1c,%

312

6.27 ± 1.24

6.28 ± 1.13

6.40 ± 1.50

6.61 ± 1.69

0.40

Uric acid, mg/dl

293

5.77 ± 1.4

5.47 ± 1.2

5.21 ± 1.4

5.26 ± 1.15

0.038

C-reactive protein,¶ mg/L

291

3.20 x3.2

3.35 x2.7

3.25 x3.37

4.24 x3.5

0.41

Current; past smokers,%

33.3; 45.7

44; 37.3

47; 37.3

55.6; 31.3

0.21

LV ejection fraction,%

243

51 ± 11.7

51.3 ± 11.4

51.8 ± 10

49.3 ± 11.6

0.63

Diabetes baseline, n,%

27; 33.3

27; 36

30; 36.1

28; 34.6

0.98