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Table 4 Logistic regression models for combined death and nonfatal events, stratified by presence of CHD at baseline, comparing eGFR with both the MDRD and CKD-EPI equations

From: Renal “hyperfiltrators” are at elevated risk of death and chronic diseases

 

Free of CHD

CHD

 

RR

95% CI

RR

95% CI

Combined events/Total at risk

34/469

66/320

eGFR with MDRD

    

Sex, male

1.32

0.61; 2.85

1.16

0.60; 2.24

Age, 8 years

1.53

1.03; 2.32

1.71

1.24; 2.35

eGFR Quartile 1*, 69 ml/min/

0.78

0.21; 2.86

1.85

0.75; 4.53

eGFR Quartile 3*, 115 ml/min/

2.25

0.94; 6.88

2.28

0.96; 5.42

eGFR Quartile 4*, 163 ml/min/

4.00

1.34; 11.9

2.72

1.08; 6.81

Hypertension, yes/no

1.34

0.62; 2.89

0.83

0.46; 1.49

Body mass index, 4 kg/m2

1.06

0.71; 1.57

1.23

0.91; 1.64

Current vs never smoking

1.37

0.52; 3.57

1.06

0.45; 2.50

Former vs never smoking

2.85

1.08; 7.56

1.06

0.45; 2.49

eGFR with CKD-EPI

    

Sex, male

1.31

0.61; 2.80

0.85

0.44; 1.62

Age, 8 years

1.78

1.13; 2.85

1.73

1.22; 2.48

eGFR Quartile 2*, 94 ml/min/1.73

2.07

0.64; 6.68

1.05

0.48; 2.31

eGFR Quartile 3*, 104 ml/min/1.73

2.84

0.87; 9.22

1.45

0.58; 3.11

eGFR Quartile 4*, 118 ml/min/1.73

6.08Ť

1.68; 22.0

1.36

0.55; 3.34

Hypertension, yes/no

1.30

0.61; 2.78

0.83

0.47; 1.48

Body mass index, 4 kg/m2

1.02

0.69; 1.53

1.20

0.90; 1.60

Current vs never smoking

1.30

0.51; 3.37

0.98

0.42; 2.29

Former vs never smoking

2.74

1.05; 7.18

0.98

0.42; 2.28

  1. *Referent is expressed for quartile 2 in the upper, for quartile 1 (70 ml/min/) in the lower model.
  2. Number of subjects in the group without and with CHD, respectively: 151/181 hypertensives; 164/144 current and 57/121 former smokers. CHD, coronary heart disease Ť p trend 0.048.