Table 3 Baseline laboratory values
Controls | CKD | CKD stage 3 | CKD stages 4-5 | CKD stage 5D | p value | p value | |
|---|---|---|---|---|---|---|---|
n =559 | n =2445 | n =937 | n =820 | n =688 | CKD vs controls | Between CKD groups | |
Creatinine (mg/dL) | 0.8 ± 0.2 | 4.1 ± 3.3 | 1.6 ± 0.4 | 3.3 ± 1.3 | 8.4 ± 2.9 | <0.001 | <0.001 |
MDRD (mL/min/1.73 m2) | 91.8 ± 16.8 | N/A | 43.5 ± 8.7 | 20.6 ± 7.5 | N/A | N/A | N/A |
Urea (mg/dL) | 37.4 ± 9.1 | 101.6 ± 48.1 | 65.3 ± 24.3 | 121.9 ± 47.5 | 126.1 ± 42.9 | <0.001 | <0.001 |
Total cholesterol (mg/dL) | 203.4 ± 35.6 | 178.3 ± 39.7 | 187.4 ± 36.5 | 179.1 ± 37.9 | 164.9 ± 42.4 | <0.001 | <0.001 |
LDL-cholesterol (mg/dL) | 127.3 ± 32.8 | 101.8 ± 33.7 | 109.6 ± 31.6 | 101.9 ± 32.7 | 91.2 ± 34.8 | <0.001 | <0.001 |
HDL-cholesterol (mg/dL) | 53.9 ± 15.4 | 49.3 ± 15.4 | 50.9 ± 15.4 | 49.2 ± 15.1 | 47.3 ± 15.6 | <0.001 | <0.001 |
No-HDL-cholesterol (mg/dL) | 150.4 ± 36.1 | 129.3 ± 37.4 | 136.8 ± 34.5 | 130.6 ± 36.3 | 117.8 ± 39.7 | <0.001 | <0.001 |
Triglycerides (mg/dL) | 115.5 ± 67.5 | 145.0 ± 82.3 | 144.7 ± 83.0 | 149.8 ± 85.7 | 139.7 ± 76.1 | <0.001 | NS |
Glucose (mg/dL) | 101.4 ± 23.6 | 107.6 ± 39.4 | 110.8 ± 37.4 | 108.4 ± 41.4 | 102.3 ± 39.2 | NS | NS |
Hemoglobin (g/dL) | 14.5 ± 1.4 | 12.8 ± 1.7 | 13.8 ± 1.7 | 12.4 ± 1.4 | 11.9 ± 1.4 | <0.001 | <0.001 |
Transferrin (mg/dL) | 283.4 ± 47.1 | 220.1 ± 48.8 | 245.9 ± 48.0 | 220.7 ± 42.2 | 193.3 ± 41.7 | <0.001 | <0.001 |
TSAT (%) | 24.9 ± 12.4 | 27.8 ± 12.5 | 25.8 ± 10.5 | 27.3 ± 10.6 | 30.4 ± 15.5 | 0.003 | <0.001 |
Ferritin (ng/mL) | 113.8 ± 116.7 | 244.2 ± 308.8 | 170.7 ± 215.1 | 190.2 ± 167.7 | 365.5 ± 440.8 | <0.001 | <0.001 |
Uric acid (mg/dL) | 5.1 ± 1.4 | 6.7 ± 1.6 | 6.8 ± 1.6 | 7.0 ± 1.6 | 6.1 ± 1.3 | <0.001 | <0.001 |
hsCRP (mg/L) | 3.4 ± 7.9 | 4.7 ± 9.3 | 3.9 ± 6.1 | 4.8 ± 9.9 | 5.6 ± 11.7 | <0.001 | 0.020 |
Albumin (g/dL) | 4.4 ± 0.3 | 4.1 ± 0.4 | 4.2 ± 0.4 | 4.1 ± 0.5 | 3.9 ± 0.5 | <0.001 | <0.001 |
Corrected calcium (mg/dL) | 9.4 ± 0.4a | 9.2 ± 0.6 | 9.5 ± 0.5 | 9.3 ± 0.6 | 9.1 ± 0.7 | <0.001 | <0.001 |
Phosphorus (mg/dL) | 3.5 ± 0.5a | 4.1 ± 1.1 | 3.4 ± 0.6 | 4.1 ± 0.8 | 4.9 ± 1.3 | <0.001 | <0.001 |
Intact PTH (pg/mL) | N/A | 181.7 ± 193.5 | 85.6 ± 69.0 | 173.5 ± 123.8 | 297.1 ± 273.2 | N/A | <0.001 |
25-hydroxi-vitamin D (ng/L) | 20.1 ± 7.9 | 16.1 ± 7.5 | 16.7 ± 7.8 | 16.2 ± 6.8 | 15.1 ± 7.4 | <0.001 | <0.001 |
1,25-hydroxi-vitamin D (pg/mL) | 33.6 ± 13.9 | 16.8 ± 10.9 | 21.5 ± 11.2 | 17.4 ± 10.0 | 8.3 ± 5.1 | <0.001 | <0.001 |