CDDP group | THD group | ||||||
---|---|---|---|---|---|---|---|
Baseline (n = 38) | 6 months (n = 38) | 12 months (n = 34) | Baseline (n = 30) | 6 months (n = 30) | 12 months (n = 29) | P | |
Dry weight (kg) | 65 ± 15.0 | 63.9 ± 14.4 | 63.4 ± 14.7 | 66.2 ± 11.9 | 64.9 ± 11.5 | 65.5 ± 12.3 | 0.07 |
BMI (kg/m 2 ) | 23.7 ± 4.0 | 23.4 ± 3.7 | 23.0 ± 3.9 | 25.6 ± 4.13 | 25.1 ± 4.07 | 25.4 ± 4.2 | 0.07 |
Total body water (L) | 44.4 ± 10.5 | 41 ± 9.6 | 43 ± 11 | 35.4 ± 6 | 33.5 ± 5.8 a | 33.8 ± 5.9 a | 0.02 |
Extracellular water (L) | 20 ± 4.5 | 18.6 ± 4.3 | 19.7 ± 4 | 17.5 ± 3.2 | 16 ± 2.8 b | 15.7 ± 2.4 b | 0.04 |
Fat mass (kg) | 11 ± 12.3 | 13 ± 11.8 | 11.4 ± 11 | 20 ± 9 | 21.4 ± 8.5 | 22.6 ± 9.4 | 0.03 |
Body cell mass (kg) | 31 ± 9.6 | 28 ± 8.9 | 29.7 ± 10.3 | 22.5 ± 6.2 | 22.7 ± 5 | 22.7 ± 5.8 | 0.02 |
Phase angle, (°) | 6.2 ± 1.3 | 6.2 ± 1.3 | 6.1 ± 1.4 | 5.0 ± 1.2 | 6 ± 0.9 | 5.8 ± 1.2 | 0.06 |
SBP (mmHg) | 139 ± 18 | 132 ± 20 | 128 ± 15 b | 136.8 ± 17.2 | 138.5 ± 18.5 | 139 ± 20.8 | 0.21 |
DBP (mmHg) | 80 ± 12 | 73 ± 10 | 74 ± 9 c | 71.6 ± 11.4 | 71.6 ± 10 | 72.9 ± 12.3 | 0.08 |
Serum creatinine (mg/dL) | 6.4 ± 1.9 | 7.0 ± 2.5 | 7.8 ± 3.0 b | 5.9 ± 1.8 | 7.8 ± 2.2 | 8.2 ± 2.4 b | 0.05 |
B.U.N. (mg/dL) | 68 ± 18 | 68 ± 16 | 70 ± 17 | 84.4 ± 18.5 | 77 ± 15.5 | 77 ± 22.9 | 0.003 |
GFR (mL/min) | 7.8 ± 1.9 | 6.7 ± 2.3 | 6.3 ± 2.1 b | 9.2 ± 4.2 | - | - | - |
eGFR (mL/min) | 9.4 ± 2.9 | 8.4 ± 3.5 a | 8.0 ± 3.4 b | 10.3 ± 3.9 | - | - | - |
Total protein (g/dL) | 6.7 ± 0.5 | 6.7 ± 0.5 | 6.8 ± 0.4 | 6.35 ± 0.52 | 6.4 ± 0.5 | 6.5 ± 0.43 | 0.004 |
Albumin (g/dL) | 3.8 ± 0.4 | 3.9 ± 0.4 | 4.1 ± 0.4 b | 3.6 ± 0.40 | 3.6 ± 0.37 | 3.7 ± 0.48 | 0.01 |
Transferrine (mg/dL) | 219 ± 53 | 203 ± 72 | 222 ± 53 | 264 ± 94 | 249 ± 43 | 251 ± 61 | 0.001 |
C3 (mg/dL) | 90 ± 20 | 91 ± 23 | 94 ± 23 | 99.6 ± 39.6 | 96 ± 35.7 | 95.9 ± 32 | 0.48 |
C4 (mg/dL) | 24 ± 7 | 24 ± 8 | 26 ± 7 | 33 ± 28 | 29 ± 18 | 29 ± 30 | 0.26 |
Total IgG (mg/dL) | 1599 ± 497 | 1590 ± 402 | 1543 ± 373 | 1440 ± 461 | 1482 ± 487 | 1409 ± 413 | 0.21 |
Lynphocytes/mm 3 | 1539 ± 651 | 1390 ± 831 | 1581 ± 537 | 1452 ± 811 | 1458 ± 622 | 1445 ± 580 | 0.38 |