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Table 4 Multivariable logistic regression analysis of renal outcomes categorized by tumor size after nephrectomy

From: Impact of partial nephrectomy on kidney function in patients with renal cell carcinoma

  Total cohort (n = 557) Tumor size ≤4 cm (n = 370) 4 cm < tumor size ≤7 cm (n = 187)
  OR (CI 95%) P value OR (CI 95%) P value OR (CI 95%) P value
AKI       
Age 0.99 (0.97-1.00) 0.149 0.99 (0.97-1.01) 0.398 0.98 (0.96-1.01) 0.210
Male 3.15 (1.92-5.17) <0.001 3.58 (1.86-6.91) <0.001 2.24 (1.13-5.26) 0.023
BMI 1.11 (1.04-1.19) 0.002 1.09 (1.00-1.19) 0.054 1.14 (1.02-1.27) 0.019
Smoking 1.01 (0.64-1.59) 0.976 0.80 (0.45-1.40) 0.429 1.56 (0.69-3.50) 0.283
Hypertension 1.39 (0.89-2.18) 0.144 1.38 (0.78-2.45) 0.275 1.43 (0.69-2.97) 0.338
Diabetes 0.68 (0.38-1.21) 0.188 0.56 (0.27-1.17) 0.122 0.98 (0.36-2.70) 0.967
Proteinuria 1.00 (0.54-1.85) 0.994 1.08 (0.49-0.34) 0.859 0.87 (0.31-2.48) 0.796
Open surgery 1.06 (0.63-1.79) 0.829 1.04 (0.54-2.01) 0.901 1.15 (0.46-2.85) 0.770
Stage III 0.69 (0.18-2.58) 0.576 0.43 (0.02-8.43) 0.575 0.93 (0.19-4.67) 0.931
Partial nephrectomy 1 [Reference]   1 [Reference]   1 [Reference]  
Radical nephrectomy 9.57(6.20-14.8) <0.001 12.8 (7.09-20.7) <0.001 5.49 (1.52-19.9) 0.009
New-onset CKD      
Age 1.06 (1.04-1.08) <0.001 1.06 (1.03-1.09) <0.001 1.06 (1.03-1.10) <0.001
Male 1.04 (0.60-1.78) 0.898 0.99 (0.46-2.13) 0.988 1.01(0.45-2.24) 0.988
BMI 1.00 (0.92-1.07) 0.884 0.99 (0.89-1.10) 0.879 0.97 (0.87-1.08) 0.580
Smoking 1.49 (-0.89-2.51) 0.131 1.62 (0.80-3.25) 0.178 1.60 (0.70-3.67) 0.266
Hypertension 0.87 (0.54-1.41) 0.564 0.98 (0.50-1.90) 0.943 0.70 (0.33-1.47) 0.345
Diabetes 1.52 (0.81-2.84) 0.190 0.97 (0.42-2.23) 0.940 3.38 (1.13-10.1) 0.030
Proteinuria 0.93 (0.48-1.78) 0.815 1.08 (0.46-2.52) 0.859 0.81 (0.26-2.54) 0.722
Open surgery 0.95 (0.49-1.83) 0.874 1.31 (0.54-3.18) 0.555 0.57 (0.21-1.54) 0.266
Stage III 0.44 (0.11-1.84) 0.262 1.36 (0.08-24.1) 0.836 0.27( 0.05-1.48) 0.131
Partial nephrectomy 1 [Reference]   1 [Reference]   1 [Reference]  
Radical nephrectomy 23.7(11.7-41.0) <0.001 24.9 (11.7-49.7) <0.001 7.03 (1.18-31.3) 0.031
≥25% decline in eGFR 1 year after surgery    
Age 1.01 (0.99-1.03) 0.309 1.01 (0.99-1.04) 0.371 1.01 (0.98-1.04) 0.655
Male 1.58 (0.91-2.74) 0.104 1.99 (0.92-4.29) 0.081 1.03 (0.45-2.38) 0.944
BMI 1.05 (0.97-1.13) 0.220 1.02 (0.92-1.13) 0.712 1.06 (0.94-1.19) 0.362
Smoking 1.10 (0.65-1.83) 0.731 0.77 (0.38-1.55) 0.469 1.85 (0.89-4.33) 0.158
Hypertension 0.85 (0.51-1.41) 0.527 0.68 (0.35-1.36) 0.277 1.07 (0.48-2.40) 0.868
Diabetes 1.57 (0.81-3.03) 0.178 1.64 (0.69-3.86) 0.261 1.50 (0.50-4.49) 0.472
Proteinuria 0.99 (0.50-1.96) 0.971 1.24 (0.50-3.07) 0.638 0.95 (0.31-2.95) 0.930
Open surgery 0.57 (0.29-1.12) 0.102 1.12 (0.46-2.74) 0.805 0.24 (0.08-0.73) 0.011
Stage III 0.77 (0.16-3.71) 0.742 0.55 (0.03-10.5) 0.690 0.69 (0.09-5.10) 0.712
Partial nephrectomy 1 [Reference]   1 [Reference]   1 [Reference]  
Radical nephrectomy 22.7 (12.7-40.7) <0.001 28.3 (14.3-56.0) <0.001 12.6 (1.45-108.9) 0.022
  1. Adjusted factors include age, sex, systolic blood pressure, diastolic blood pressure, body mass index, history of smoking, hypertension, and diabetes mellitus, urine protein level, type of surgical procedure, and pathologic stage.
  2. Abbreviations: OR odds ratio, CI confidential interval, AKI acute kidney injury, CKD chronic kidney disease, eGFR estimated glomerular filtration rate, BMI body mass index.