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Table 4 Multivariable logistic regression analysis of renal outcomes categorized by tumor size after nephrectomy

From: Impact of partial nephrectomy on kidney function in patients with renal cell carcinoma

 

Total cohort (n = 557)

Tumor size ≤4 cm (n = 370)

4 cm < tumor size ≤7 cm (n = 187)

 

OR (CI 95%)

P value

OR (CI 95%)

P value

OR (CI 95%)

P value

AKI

      

Age

0.99 (0.97-1.00)

0.149

0.99 (0.97-1.01)

0.398

0.98 (0.96-1.01)

0.210

Male

3.15 (1.92-5.17)

<0.001

3.58 (1.86-6.91)

<0.001

2.24 (1.13-5.26)

0.023

BMI

1.11 (1.04-1.19)

0.002

1.09 (1.00-1.19)

0.054

1.14 (1.02-1.27)

0.019

Smoking

1.01 (0.64-1.59)

0.976

0.80 (0.45-1.40)

0.429

1.56 (0.69-3.50)

0.283

Hypertension

1.39 (0.89-2.18)

0.144

1.38 (0.78-2.45)

0.275

1.43 (0.69-2.97)

0.338

Diabetes

0.68 (0.38-1.21)

0.188

0.56 (0.27-1.17)

0.122

0.98 (0.36-2.70)

0.967

Proteinuria

1.00 (0.54-1.85)

0.994

1.08 (0.49-0.34)

0.859

0.87 (0.31-2.48)

0.796

Open surgery

1.06 (0.63-1.79)

0.829

1.04 (0.54-2.01)

0.901

1.15 (0.46-2.85)

0.770

Stage III

0.69 (0.18-2.58)

0.576

0.43 (0.02-8.43)

0.575

0.93 (0.19-4.67)

0.931

Partial nephrectomy

1 [Reference]

 

1 [Reference]

 

1 [Reference]

 

Radical nephrectomy

9.57(6.20-14.8)

<0.001

12.8 (7.09-20.7)

<0.001

5.49 (1.52-19.9)

0.009

New-onset CKD

     

Age

1.06 (1.04-1.08)

<0.001

1.06 (1.03-1.09)

<0.001

1.06 (1.03-1.10)

<0.001

Male

1.04 (0.60-1.78)

0.898

0.99 (0.46-2.13)

0.988

1.01(0.45-2.24)

0.988

BMI

1.00 (0.92-1.07)

0.884

0.99 (0.89-1.10)

0.879

0.97 (0.87-1.08)

0.580

Smoking

1.49 (-0.89-2.51)

0.131

1.62 (0.80-3.25)

0.178

1.60 (0.70-3.67)

0.266

Hypertension

0.87 (0.54-1.41)

0.564

0.98 (0.50-1.90)

0.943

0.70 (0.33-1.47)

0.345

Diabetes

1.52 (0.81-2.84)

0.190

0.97 (0.42-2.23)

0.940

3.38 (1.13-10.1)

0.030

Proteinuria

0.93 (0.48-1.78)

0.815

1.08 (0.46-2.52)

0.859

0.81 (0.26-2.54)

0.722

Open surgery

0.95 (0.49-1.83)

0.874

1.31 (0.54-3.18)

0.555

0.57 (0.21-1.54)

0.266

Stage III

0.44 (0.11-1.84)

0.262

1.36 (0.08-24.1)

0.836

0.27( 0.05-1.48)

0.131

Partial nephrectomy

1 [Reference]

 

1 [Reference]

 

1 [Reference]

 

Radical nephrectomy

23.7(11.7-41.0)

<0.001

24.9 (11.7-49.7)

<0.001

7.03 (1.18-31.3)

0.031

≥25% decline in eGFR 1 year after surgery

   

Age

1.01 (0.99-1.03)

0.309

1.01 (0.99-1.04)

0.371

1.01 (0.98-1.04)

0.655

Male

1.58 (0.91-2.74)

0.104

1.99 (0.92-4.29)

0.081

1.03 (0.45-2.38)

0.944

BMI

1.05 (0.97-1.13)

0.220

1.02 (0.92-1.13)

0.712

1.06 (0.94-1.19)

0.362

Smoking

1.10 (0.65-1.83)

0.731

0.77 (0.38-1.55)

0.469

1.85 (0.89-4.33)

0.158

Hypertension

0.85 (0.51-1.41)

0.527

0.68 (0.35-1.36)

0.277

1.07 (0.48-2.40)

0.868

Diabetes

1.57 (0.81-3.03)

0.178

1.64 (0.69-3.86)

0.261

1.50 (0.50-4.49)

0.472

Proteinuria

0.99 (0.50-1.96)

0.971

1.24 (0.50-3.07)

0.638

0.95 (0.31-2.95)

0.930

Open surgery

0.57 (0.29-1.12)

0.102

1.12 (0.46-2.74)

0.805

0.24 (0.08-0.73)

0.011

Stage III

0.77 (0.16-3.71)

0.742

0.55 (0.03-10.5)

0.690

0.69 (0.09-5.10)

0.712

Partial nephrectomy

1 [Reference]

 

1 [Reference]

 

1 [Reference]

 

Radical nephrectomy

22.7 (12.7-40.7)

<0.001

28.3 (14.3-56.0)

<0.001

12.6 (1.45-108.9)

0.022

  1. Adjusted factors include age, sex, systolic blood pressure, diastolic blood pressure, body mass index, history of smoking, hypertension, and diabetes mellitus, urine protein level, type of surgical procedure, and pathologic stage.
  2. Abbreviations: OR odds ratio, CI confidential interval, AKI acute kidney injury, CKD chronic kidney disease, eGFR estimated glomerular filtration rate, BMI body mass index.
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BMC Nephrology

ISSN: 1471-2369

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