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Table 2 Long-term outcome studies of pediatric Acute Kidney Injury (AKI)

From: Long-term risk of chronic kidney disease and mortality in children after acute kidney injury: a systematic review

Author, Year published

AKI definition

Hospitalized cohort

Detailed follow-up cohort

 

Outcomes (%)

HospitalMortality, (%)

Acutely dialyzed during hospitalization (%)

Enrolled (%)

Mean follow-up (years)

Long-term mortality, (%)

# of Patients with follow-up

Abnormal GFR definition

Abnormal GFR

GFR <60

ESRD

Proteinuria

HTN

Askenazi [14], 2006

eGFR <75

71/245, (29)

21

17

4

35/174, (20)

29

GFR <90

14

7

9

28

21

Buysse [50], 2008

∆ SCr 100%

25

71

10

16

GFR <90

6

0

0

19

13

Georgaki-Angelaki [45], 1989

RRT

17/70, (24)

100

19

10

10

GFR <90

20

0

0

0

Mammen [41], 2012

AKIN criteria

40/425, (9)

17

33

2*

126

GFR ≤90

39

1

0

10

3

Mel [36], 2013

RRT

35/76, (46)

100

61

5*

15/41, (37)

25

GFR <90

4

0

0

0

0

Miler, 1997

AKIΩ

28/118, (24)

34

67

6

4/64, (6)

60

GFR <90

46

6

0

3

Shaw [44], 1991

RRT

23/34, (68)

100

100

3

0/11, (0)

11

abnormal mGFR

9

0

0

0

9

Slack [51], 2005

RRT

6/21, (29)

100

80

4*

12 β

GFR <90

25

8

0

17

25

Viaud [46], 2011

RRT

16/52, (30)

100

36

16*

0/36, (0)

13

GFR <90

61

23

0

54

15

Wedekin [52], 2008

SCr >1.1

26/70, (37)

17

100

3*

7/44 (16)

44

abnormal SCr

0

  1. The original hospitalized cohort is described along with the detailed follow-up cohort. The detailed follow-up cohort was assessed for long-term outcomes. Abbreviations: h, hour, RRT, renal replacement therapy, GFR, glomerular filtration rate (ml/min/1.73 m2), SCr, serum creatinine (in mg/dl. 1 mg, HTN, hypertension, UOP, urine output, AKIN criteria, Acute Kidney Injury Network classification system: ∆ SCr >0.3 mg/dL in 48 h, ∆ SCr ≥50%, or UOP <0.5 ml/kg/hr X 6 h, Ω, AKI diagnosed by “generally accepted criteria”, F/U, follow-up, …,not available, β, only patients with abnormal SCr at PICU discharge were followed, Enrolled (%) = # of patients with follow-up/# of patients who survived AKI admission, *, median.