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Table 3 Risk factors for HRQoL, linear regression model

From: Kidney function as an underestimated factor for reduced health related quality of life in patients with Fabry disease

 

Physical functioning

Role physical

Bodily pain

General health

 

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

Age (year)

−0.1 (−0.5; 0.4)

--

−0.2 (−1.0; 0.6)

--

0.3 (−0.3; 0.8)

--

−0.03 (−0.4; 0.4)

--

Gender (male)

−14.8 (−25.6; −4.0)

−1.7 (−12.1; 8.6)

−33.2 (−51.6; −14.9)

−17.1 (−37.1; 2.9)

−18.1 (−31.9; −4.3)

0.1 (−13.1; 13.2)

−21.6 (−30.8; −12.4)

−12.4 (−22.7; −2.1)

Diagnosis (month) a

−2.4 (−6.8; 1.9)

--

0.1 (−7.6; 7.8)

--

0.3 (−5.3; 5.9)

--

−3.3 (−7.2; 0.73)

--

Kidney function b

        

<60 vs. >60 ml/min/1.73 m2

−25.6 (−39.8; −11.4)

−16.3 (−29.9; −2.7)

−25.1 (−52.6; 2.5)

−14.8 (−41.1; 11.4)

−14.0 (−33.7; 5.7)

−0.9 (−18.1; 16.3)

−15.8 (−29.4; −2.1)

−9.3 (−22.7; 4.1)

RRT vs. >60 ml/min/1.73 m2

−31.9 (−46.7; −17.0)

−22.7 (−39.6; −5.9)

−48.2 (−78.6; −17.8)

−34.1 (−66.6; −1.5)

−36.3 (−57.0; −15.6)

−32.5 (−53.8; −11.2)

−32.3 (−46.7; −18.0)

−28.8 (−45.4; −12.2)

Vascular event

        

Minorc

−4.4 (−17.7; 8.9)

4.3 (−7.2; 15.8)

−9,5 (−33.7; 14.6)

−10.5 (−32.7; 11.7)

−9.1 (−26.3; 8.0)

−2.6 (−17.1; 11.9)

−10.3 (−23.0; 2.5)

−6.6 (−18.4; 5.1)

Majord

10.2 (−18.0; 38.3)

18.4 (−3.7; 40.6)

2.4 (−48.6; 53.4)

19.1 (−23.6; 61.8)

18.3 (−18.0; 54.7)

24.6 (−3.4; 52.5)

−12.8 (−39.1; 13.5)

−5.0 (−26.7; 16.8)

Pain

−23.3 (−23.3; −13.3)

−14.4 (−24.4; −4.4)

−37.7 (−56.3; −19.1)

−19.9 (−39.2; −0.6)

−37.2 (−49.6; −24.8)

−28.9 (−41.6; −16.3)

−22.2 (−32.4; −12.2)

−12.5 (−22.6; −2.5)

Pain-therapy

−20.1 (−32.1; −8.1)

−10.4 (−22.0; 1.1)

−38.8 (−58.6; −18.0)

−16.4 (−38.6; 5.8)

−26.0 (−40.9; −11.1)

−10.3 (−24.8; 4.3)

−19.2 (−30.3; −8.1)

−2.8 (−14.2; 8.7)

 

Vitality

Social functioning

Role emotional

Mental health

 

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

Univariate

Multivariate

Age (year)

−0.1 (−0.5; 0.3)

--

−0.1 (−0.6; 0.4)

--

−0.5 (−1.2; 0.2)

--

−0.1 (−0.4; 0.3)

--

Gender (male)

−12.1 (−22.3; −1.9)

0.5 (−10.6; 11.6)

−18.2 (−29.8; −6.5)

−4.2 (−15.6; 7.2)

−22.8 (−40.1; −5.5)

−8.6 (−26.9; 9.8)

−7.7 (−16.1; 0.8)

−0.9 (−10.3; 8.5)

Diagnosis (month) a

−1.1 (−5.2; 3.1)

--

0.3 (−4.5; 5.1)

--

−4.6 (−11.6; 2.3)

--

0.7 (−2.7; 4.0 )

--

Kidney function b

        

<60 vs. >60 ml/min/1.73 m2

−6.7 (−21.1; 7.7)

−1.5 (−15.9; 13.0)

−3.9 (−19.6; 12.1)

3.0 (−11.9; 18.0)

−15.6 (−40.1; 8.8)

−6.6 (−30.4; 17.2)

−2.0 (−14.0; 10.1)

1.9 (−10.4; 14.2)

RRT vs. >60 ml/min/1.73 m2

−25.3 (−40.4; −10.2)

−24.5 (−42.4; −6.6)

−41.5 (−58.3; −24.7)

−46.2 (−64.7; −27.6)

−45.7 (−71.3; −20.0)

−45.0 (−74.6; −15.5)

−17.4 (−30.0; −4.8)

−15.8 (−31.0; −0.6)

Vascular event

        

Minorc

−1.0 (−13.8; 11.9)

−0.7 (−13.4; 12.0)

−0.66 (−15.5; 14.2)

0.5 (−12.1; 13.2)

−4.1 (−25.6; 17.5)

0.4 (−19.7; 20.5)

−3.0 (−13.6; 7.6)

−1.5 (−12.3; 9.3)

Majord

−13.0 (−39.5; 13.5)

−14.1 (−37.7; 9.4)

10.8 (−20.7; 42.3)

11.2 (−13.1; 35.6)

5.0 (−40.7; 50.6)

7.2 (−31.6; 46.0)

−5.1 (−26.9; 16.7)

−5.4 (−25.4; 14.6)

Pain

−19.8 (−29.7; −10.0)

−14.8 (−25.7; −3.9)

−20.0 (−31.8; −8.2)

−9.3 (−20.3; 1.8)

−20.8 (−38.1; −3.5)

−5.1 (−22.8; 12.6)

−8.1 (−16.7; 0.5)

−1.6 (−10.9; 7.6)

Pain-therapy

−10.2 (−21.9; 1.4)

−0.6 (−13.0; 11.7)

−14.6 (−28.1; −1.1)

−7.6 (−20.3; 5.1)

−14.6 (−34.6; 5.3)

−8.1 (−28.4; 12.2)

−6.6 (−16.0; 2.8)

−4.8 (−15.3; 5.6)

 

Physical component summary

Mental component summary

 

Univariate

Multivariate

Univariate

Multivariate

Age (year)

0.03 (−0.2; 0.2)

--

−0.1 (−0.39; 0.1)

--

Male gender

−8.9 (−13.8; −4.0)

−2.4 (−7.3; 2.5)

−4.9 (−9.8; −0.02)

−0.2 (−6.2; 4.5)

Diagnosis (month) a

−0.6 (−2.7; 1.4)

--

−0.3 (−2.2; 1.7)

--

Kidney function b

    

<60 vs. >60 ml/min/1.73 m2

−10.4 (−17.3; −3.4)

−6.2 (−12.5; 0.1)

1.1 (−5.7; 7.9)

2.8 (3.5; −4.1)

RRT vs. >60 ml/min/1.73 m2

−16.0 (−23.7; −8,4)

−11.8 (−19.6; −4.0)

−14.3 (−21.8; −6.8)

−13.3 (−21.8; −4.7)

Vascular event

    

Minorc

−2.9 (−9.5; 3.7)

−0.1 (−5.5; 5.4)

−0.6 (−6.8; 5.6)

−1.1 (−7.1; 4.9)

Majord

3.3 (−10.3; 16.8)

8.2 (−2.0; 18.4)

−1.1 (−13.9; 11.7)

−3.4 (−14.6; 7.8)

Pain

−14.3 (−18.9; −9.7)

−9.1 (−13.8; −4.3)

−4.1 (−9.0; 0.9)

−1.1 (−6.3; 4.1)

Pain-therapy

−12.2 (−17.7; 6.8)

−5.5 (−10.9; −0.1)

−1.8 (−7.4; 3.7)

−0.4 (−6.3; 5.6)

  1. Data are beta-coefficients with respective 95% confidence interval (CI), significant values (p < 0.05) bolded.
  2. aDiagnosis Fabry disease, logarithmic form.
  3. bPatient with kidney transplantation classified as RRT.
  4. cHistory of transient ischemic attack (TIA), angina pectoris, significant cardiac procedure without coronary stent, arrhythmia.
  5. dHistory of stroke, myocardial infarction, coronary stent, coronary bypass surgery, ICD-implantation.