Determination of vancomycin and gentamicin clearance in an in vitro, closed loop dialysis system

BMC Nephrology

Table 2 The concentration of vancomycin and gentamicin at different time interval in different conditions

Condition	Filter	Sol	Time (min)	BFR (mL/min)	DFR (mL/min)	Vanco (ug/mL)	TG (ug/mL)
C1	Poly	SBS	0	400	600	20.04 ± 0.86	26.65 ± 1.69
	Poly	SBS	180	400	600	BLQ	0.51 ± 0
	Poly	Dial	0	400	600	BLQ	BLQ
	Poly	Dial	180	400	600	1.35 ± 0.41	1.31 ± 0.18
C2	Poly	SBS	0	500	800	31.91 ± 2.5	35.93 ± 0.13
	Poly	SBS	180	500	800	BLQ	0.53 ± 0.02
	Poly	Dial	0	500	800	BLQ	BLQ
	Poly	Dial	180	500	800	1.06 ± 0.05	0.99 ± 0
C3	Opt^*	SBS	0	400^*	600^*	23.74 ± 5.27	25.41 ± 3.47
	Opt	SBS	180	400	600	BLQ	0.52 ± 0.01
	Opt	Dial	0	400	600	BLQ	BLQ
	Opt	Dial	180	400	600	1.20 ± 1	1.14 ± 0.93
C4	Opt	SBS	0	500	800	30.75 ± 0.43	36.97 ± 0.18
	Opt	SBS	180	500	800	BLQ	0.51 ± 0
	Opt	Dial	0	500	800	BLQ	BLQ
	Opt	Dial	180	500	800	0.91 ± 0.08	0.94 ± 0.15

UFR is constant at rate of 300 ml/hr except for the one condition. ^*UFR was 250 mL/hr. Sol: Solution; Poly: Polyflux filter; Opt: Optiflux filter; Dial: Dialysate; Vanco: Mean vancomycin concentration; TG: Mean total gentamicin concentration; BLQ: Below the lower limit of quantification.

ISSN: 1471-2369