Determination of vancomycin and gentamicin clearance in an in vitro, closed loop dialysis system

BMC Nephrology

Table 3 Summary of the quantity of vancomycin and gentamicin using the mass balance equation and dialytic clearance

Condition	Filter	Sol	BFR (mL/min)	DFR (mL/min)	Vanco (mg)	Gent (mg)	Cl_Vanc(mL/min)	Cl_Gent(mL/min)
C1	Poly	Dial	400	600	147.0 ± 44.7	142.7 ± 20	82.1	58.2
C2	Poly	Dial	500	800	152.9 ± 7.2	142.7 ± 1.02	53.3	43.5
C3	Opt^*	Dial	400^*	600^*	131.0 ± 108.4^*	124.0 ± 101.5^*	65.3^*	56.6^*
C4	Opt	Dial	500	800	131.9 ± 12.3	137.0 ± 21.5	47.7	40.6

UFR is constant at rate of 300 ml/hr except for the one condition. ^*UFR was 250 ml/hr. Sol: Solution; Poly: Polyflux filter; Opt: Optiflux filter; Dial: Dialysate; Vanco: Vancomycin concentration; Gent: Total Gentamicin concentration; BLQ: Below the lower limit of quantification; Cl_Vanc: Mean Vancomycin Clearance; Cl_Gent: Mean Gentamicin clearance.

ISSN: 1471-2369