From: Is the inflammasome a potential therapeutic target in renal disease?
P2X7 | Disease | Species | Antagonist/genetic deletion | Effect | Renal localization of inflammasome component |
---|---|---|---|---|---|
Harada [75] | TNF-α stimulation | Rat | - | NA | Mesangial cells |
Gonclaves [76] | Unilateral ureteric obstruction | Mouse | P2X7 −/− | Beneficial | PTEC |
Vonend [77] | Hypertension | Rat | - | NA | Glomerular podocytes |
Diabetes mellitus | |||||
Turner [78] | Experimental glomerulonephritis | Mouse | - | NA | Glomeruli and infiltrating macrophages |
Rat | |||||
Glomeruli | |||||
 | Lupus nephritis | Humans | - | NA | Glomeruli |
PTEC | |||||
Taylor [70] | Experimental glomerulonephritis | Rat | Antagonist | Beneficial | - |
 |  | Mouse | P2X7 −/− |  |  |
NLRP3 | Disease | Species | Antagonist/genetic deletion | Effect | Renal localization of inflammasome component |
Deplano [79] | Glomerulonephritis | Rat | Genetic susceptible strain (cf. Protected strain) | NA | Glomeruli and bone marrow derived macrophages |
Vilaysane A [80] | Non-diabetic acute and chronic kidney diseases | Human | NA | NA | PTEC |
Vilaysane A [80] | Unilateral ureteric obstruction | Mice | NLRP3−/− | Beneficial | PTEC |
Iyer S [81] | Ischaemia- reperfusion injury | Mice | NLRP3−/− | Beneficial | - |
Jalilian [82] | None | Dog | NA | NA | Epithelial cells |
IL-1 | Disease | Species | Antagonist/genetic deletion | Effect | Renal localization of inflammasome component |
Yamagishi H [83] | Unilateral ureteric obstruction | Mouse | IL-1 RA | Beneficial | PTEC |
Haq M [44] | Ischaemia- reperfusion injury | Mouse | IL-1 RA | Beneficial | - |
IL-1R −/− | |||||
Chen A [46] | IgA nephropathy | Mice | IL-1 RA | Beneficial | - |
Matsumoto [84] | Glomerulonephritis | Human | NA | NA | Â |
Tam [85] | Glomerulonephritis | Rat | NA | N/A | Â |
Lan [86] | Glomerulonephritis | Rat | IL-1RA | Beneficial | Â |
Karkar [87] | Glomerulonephritis | Rat | Antibody | Beneficial | Â |
Karkar [88] | Glomerulonephritis | Rat | IL-1RA and soluble IL-1R | Beneficial | Â |
Tam [89] | |||||
Timoshanko JR [48] | Crescentic glomerulonephritis | Mice | IL-1β −/− | Beneficial | - |
IL-1R −/− | |||||
Lichtnekert [47] | Anti- GBM disease | Mice | NLRP3 −/− | No effect | Renal dendritic cells |
Caspase1 −/− | No effect | ||||
ASC −/− | No effect | ||||
IL-1R1 −/− | Benefit | ||||
Il-18 −/− | Mild benefit | ||||
Schorlemmer H [90] | SLE-like disease | Mice | IL-1 RA | Beneficial | - |
Furuichi [43] | Ischaemia- reperfusion injury | Mice | IL-1αβ −/− | Beneficial | glomeruli and cortical arterioles |
IL-1RA −/− | |||||
Rusai [45] | Ischaemia- reperfusion injury | Rats | IL-1 RA | Beneficial | - |
Granfeldt [91] | Endotoxaemia | Pigs | NA | NA | Endothelial cells of the cortical arterioles were positive for IL-1β |
IL-1ra was detected in the glomerulus and tubular cells | |||||
Hertting [92] | E.Coli pyelonephritis | Mice | IL-1β −/− | Harmful | - |
Caspase-1 | Disease | Species | Antagonist/genetic deletion | Effect | Renal localization of inflammasome component |
Homsi [93] | Glycerol- induced AKI | Rats | Caspase-1 inhibitor | Beneficial | Constitutive tubular expression of IL-18 |
Induction of tubular IL-1β | |||||
Wang [94] | Endotoxaemia | Mice | Caspase 1 −/− | Beneficial | - |
IL-1 Ra | No effect | ||||
IL-18 antiserum | No effect | ||||
Gauer [95] | None | Humans | NA | NA | Collecting duct alpha- and beta-intercalated cells express P2X7, IL-18 |
Edelstein [96] | Hypoxia | Mice | Caspase 1 −/− | Beneficial | IL-18 in PTEC |
 |  |  | IL-18 binding protein | No effect |  |
IL-18 | Disease | Species | Antagonist/genetic deletion | Effect | Renal localization of inflammasome component |
Bani-Hani A [68] | Unilateral ureteric obstruction | Mice | Transgenic mice overexpressing human IL-18-binding protein | Beneficial | TECs |
Wu H [66] | Ischaemia- reperfusion injury | Mice | IL-18 −/− | Beneficial | TECs |
IL-18 −/− BM chimera | Beneficial | ||||
IL-18-binding protein | Beneficial | ||||
Sugiyama M [67] | Bovine serum albumin-induced glomerulonephritis | Mice | IL-18R −/− | Beneficial | - |
Kinoshita K [97] | Autoimmune disease | Mice | IL-18R −/− | Beneficial | - |
Wang [61] | Ischaemia-reperfusion injury | Rat | IL-18-binding protein | Beneficial | - |
Zhang [60] | Unilateral ureteric obstruction | Mice | Overexpress human IL-18-binding protein isoform a | Beneficial | - |
VanderBrink [98] | Unilateral ureteric obstruction | Mice | IL-18 −/− | NA | TECs |
ASC | Disease | Species | Antagonist/genetic deletion | Effect | Renal localization of inflammasome component |
Iyer S [81] | Ischaemia- reperfusion injury | Mice | ASC −/− | Beneficial | - |