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Table 2 Inflammasome and inflammatory renal diseases

From: Is the inflammasome a potential therapeutic target in renal disease?

P2X7 Disease Species Antagonist/genetic deletion Effect Renal localization of inflammasome component
Harada [75] TNF-α stimulation Rat - NA Mesangial cells
Gonclaves [76] Unilateral ureteric obstruction Mouse P2X7 −/− Beneficial PTEC
Vonend [77] Hypertension Rat - NA Glomerular podocytes
Diabetes mellitus
Turner [78] Experimental glomerulonephritis Mouse - NA Glomeruli and infiltrating macrophages
Rat
Glomeruli
  Lupus nephritis Humans - NA Glomeruli
PTEC
Taylor [70] Experimental glomerulonephritis Rat Antagonist Beneficial -
   Mouse P2X7 −/−   
NLRP3 Disease Species Antagonist/genetic deletion Effect Renal localization of inflammasome component
Deplano [79] Glomerulonephritis Rat Genetic susceptible strain (cf. Protected strain) NA Glomeruli and bone marrow derived macrophages
Vilaysane A [80] Non-diabetic acute and chronic kidney diseases Human NA NA PTEC
Vilaysane A [80] Unilateral ureteric obstruction Mice NLRP3−/− Beneficial PTEC
Iyer S [81] Ischaemia- reperfusion injury Mice NLRP3−/− Beneficial -
Jalilian [82] None Dog NA NA Epithelial cells
IL-1 Disease Species Antagonist/genetic deletion Effect Renal localization of inflammasome component
Yamagishi H [83] Unilateral ureteric obstruction Mouse IL-1 RA Beneficial PTEC
Haq M [44] Ischaemia- reperfusion injury Mouse IL-1 RA Beneficial -
IL-1R −/−
Chen A [46] IgA nephropathy Mice IL-1 RA Beneficial -
Matsumoto [84] Glomerulonephritis Human NA NA  
Tam [85] Glomerulonephritis Rat NA N/A  
Lan [86] Glomerulonephritis Rat IL-1RA Beneficial  
Karkar [87] Glomerulonephritis Rat Antibody Beneficial  
Karkar [88] Glomerulonephritis Rat IL-1RA and soluble IL-1R Beneficial  
Tam [89]
Timoshanko JR [48] Crescentic glomerulonephritis Mice IL-1β −/− Beneficial -
IL-1R −/−
Lichtnekert [47] Anti- GBM disease Mice NLRP3 −/− No effect Renal dendritic cells
Caspase1 −/− No effect
ASC −/− No effect
IL-1R1 −/− Benefit
Il-18 −/− Mild benefit
Schorlemmer H [90] SLE-like disease Mice IL-1 RA Beneficial -
Furuichi [43] Ischaemia- reperfusion injury Mice IL-1αβ −/− Beneficial glomeruli and cortical arterioles
IL-1RA −/−
Rusai [45] Ischaemia- reperfusion injury Rats IL-1 RA Beneficial -
Granfeldt [91] Endotoxaemia Pigs NA NA Endothelial cells of the cortical arterioles were positive for IL-1β
IL-1ra was detected in the glomerulus and tubular cells
Hertting [92] E.Coli pyelonephritis Mice IL-1β −/− Harmful -
Caspase-1 Disease Species Antagonist/genetic deletion Effect Renal localization of inflammasome component
Homsi [93] Glycerol- induced AKI Rats Caspase-1 inhibitor Beneficial Constitutive tubular expression of IL-18
Induction of tubular IL-1β
Wang [94] Endotoxaemia Mice Caspase 1 −/− Beneficial -
IL-1 Ra No effect
IL-18 antiserum No effect
Gauer [95] None Humans NA NA Collecting duct alpha- and beta-intercalated cells express P2X7, IL-18
Edelstein [96] Hypoxia Mice Caspase 1 −/− Beneficial IL-18 in PTEC
    IL-18 binding protein No effect  
IL-18 Disease Species Antagonist/genetic deletion Effect Renal localization of inflammasome component
Bani-Hani A [68] Unilateral ureteric obstruction Mice Transgenic mice overexpressing human IL-18-binding protein Beneficial TECs
Wu H [66] Ischaemia- reperfusion injury Mice IL-18 −/− Beneficial TECs
IL-18 −/− BM chimera Beneficial
IL-18-binding protein Beneficial
Sugiyama M [67] Bovine serum albumin-induced glomerulonephritis Mice IL-18R −/− Beneficial -
Kinoshita K [97] Autoimmune disease Mice IL-18R −/− Beneficial -
Wang [61] Ischaemia-reperfusion injury Rat IL-18-binding protein Beneficial -
Zhang [60] Unilateral ureteric obstruction Mice Overexpress human IL-18-binding protein isoform a Beneficial -
VanderBrink [98] Unilateral ureteric obstruction Mice IL-18 −/− NA TECs
ASC Disease Species Antagonist/genetic deletion Effect Renal localization of inflammasome component
Iyer S [81] Ischaemia- reperfusion injury Mice ASC −/− Beneficial -
  1. Abbreviations: PTEC Proximal tubular epithelial cells, NLRP3 Nod-like receptor protein 3, IL-1RA Interleukin 1 receptor antitagonist, ARF Acute renal failure, TEC Tubular epithelial cell, BM Bone marrow.