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Table 2 Biochemical parameters and alfacalcidol dose at baseline, at three months and at six months after the switch to oral administration

From: Comparison of oral and intravenous Alfacalcidol in chronic hemodialysis patients

Serum parameters

Baseline IV alfacalcidol administration

3 months after switch to oral alfacalcidol

6 months after switch to oral alfacalcidol

Calcium, mmol/L (SD)

2.34 (0.17)

2.40 (0.18)**

2.43 (0.17)**

Phosphorus, mmol/L (SD)

1.49 (0.44)

1.58 (0.44)

1.57 (0.50)

Ca x PO4 (SD)

3.49 (1.06)

3.78 (1.07)*

3.77 (1.18)

Intact PTH, pmol/L (SD)

79.7 (59)

58.5 (56)**

78.2 (77)

Alkaline phosphatise (SD)

142.3 (103)

127.7 (96)*

130.2 (103)*

25(OH)D3, nmol/L (SD)

55 (20)

57 (24)

50 (21)**

1,25(OH) 2D3 (pmol/L) (SD)

32 (19)

38 (17)*

40 (18)*

Mean alfacalcidol dose (SD)

2.1 μg 3 times a week (0.86)

1.87 μg 3 times a week (0.92)*

1.56 μg 3 times a week (0.79)**

  1. Ca x PO 4 , Phosphocalcic product, SD, Standard deviation.
  2. *P < 0.05 compared to baseline.
  3. **P < 0.001 compared to baseline.