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Table 2 Univariate and multivariate ordinal logistic regression analyses for determining the predictive factors of epithelial-to-mesenchymal transition

From: Shorter daily dwelling time in peritoneal dialysis attenuates the epithelial-to-mesenchymal transition of mesothelial cells

 

Univariate

Multivariated

 

OR (95% CI)

P valve

OR (95% CI)

P valve

Age (year)

0.95 (0.89-1.00)

0.049*

0.94 (0.88-1.00)

0.08

Gender

0.59 (0.19-1.79)

0.35

  

BMI (kg/m2)

1.07 (0.93-1.23)

0.29

  

Diabetes Mellitus (yes/no)

2.29 (0.75-6.98)

0.14

0.29 (0.07-1.26)

0.10

Hypertension (yes/no)

0.36 (0.06-2.00)

0.25

  

Albumin (g/dL)

2.2 (0.53-9.45)

0.26

  

Hemoglobin (g/dL)

1.00 (0.71-1.41)

0.98

  

Residual renal function

1.00 (0.08-1.27)

0.98

  

APD (yes/no)

1.00 (0.32-3.16)

0.98

  

Glucose load (Kg)a

1.06 (0.86-1.31)

0.53

  

PD duration (months)

0.99 (0.96-1.02)

0.61

  

Total duration of dialysate exposure (months)b

1.00 (0.99-1.00)

0.37

1.00 (0.99-1.00)

0.61

Dwelling time (grouping)c

    

  Group 2 to 1

5.01 (1.22-20.56)

0.025*

7.37 (1.35-40.20)

0.021*

  Group 3 to 1

6.54 (1.60-26.70)

0.009*

6.16 (1.20-31.49)

0.028*

Peritonitis (times)

0.78 (0.51-1.20)

0.26

0.68 (0.41-1.13)

0.14

RAAS inhibitor (yes/no)

2.02 (0.61-6.60)

0.24

  

Statin (yes/no)

0.94 (0.26-3.33)

0.92

  
  1. Abbreviations: OR odds ratio, CI confidence intervals, BMI body mass index, APD automatic peritoneal dialysis, PD peritoneal dialysis, RAAS inhibitor renin-angiotensin-aldosterone system inhibitor.
  2. Notes: aTotal peritoneal glucose exposure (kg); bTotal peritoneum dialysate contact time; cGroup 1: daily dwelling time <24 h (ranging from 8–20 h), Group 2: daily dwelling time of 24 h with icodextrin-containing solution once daily, and Group 3: daily dwelling time of 24 h with all conventional dialysate; and *P < 0.05; dSignificant predictors (P < 0.2) in univariate analysis and other possible factors that may influence EMT of the MCs, such as total dialysate exposure duration, and episodes of peritonitis were included in the multivariate analysis.