Parameter | Oseltamivir | Oseltamivir carboxylate | ||||
---|---|---|---|---|---|---|
Oseltamivir 2.5Â mg | Oseltamivir 5Â mg | Oseltamivir 10Â mg | Oseltamivir 2.5Â mg | Oseltamivir 5Â mg | Oseltamivir 10Â mg | |
Cmax (ng/mL) | 1.81 (0.92) | 4.68 (3.28) | 8.40 (3.03) | 181.07 (96.38) | 410.35 (206.54) | 599.23 (360.64) |
Tmax (hr) | 1.00 [1.00, 1.55] | 1.06 [1.00, 1.13] | 1.00 [1.00, 1.55] | 44.11 [24.00, 44.25] | 43.99 [24.0, 44.05] | 24.01 [24.00, 43.68] |
AUClast (ng h/mL) | 3.24 (0.81) | 9.60 (6.83) | 15.47 (5.48) | 7697.12 (3930.52) | 12497.57 (3537.45) | 25394.42 (12912.41) |
AUCHD (ng h/mL) | NA | NA | NA | 288.52 (119.78) | 458.82 (226.88) | 784.87 (205.39) |
CL/F (L/hr) | 554.41 (37.86) | 558.27 (252.14) | 645.73 (161.19) | NA | NA | NA |
CLHD (mL/hr) | NA | NA | NA | 5.14 (1.87) | 6.41 (3.43) | 6.92 (1.30) |
Drug excreted by dialysis (%)* | NA | NA | NA | 0.06 (0.04) | 0.05 (0.02) | 0.04 (0.01) |