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Table 2 Pharmacokinetic parameters of oseltamivir and oseltamivir carboxylate following a single oral administration of 2.5, 5, and 10 mg of oseltamivir

From: Dose selection method for pharmacokinetic study in hemodialysis patients using a subpharmacological dose: oseltamivir as a model drug

Parameter

Oseltamivir

Oseltamivir carboxylate

Oseltamivir 2.5 mg

Oseltamivir 5 mg

Oseltamivir 10 mg

Oseltamivir 2.5 mg

Oseltamivir 5 mg

Oseltamivir 10 mg

Cmax (ng/mL)

1.81 (0.92)

4.68 (3.28)

8.40 (3.03)

181.07 (96.38)

410.35 (206.54)

599.23 (360.64)

Tmax (hr)

1.00 [1.00, 1.55]

1.06 [1.00, 1.13]

1.00 [1.00, 1.55]

44.11 [24.00, 44.25]

43.99 [24.0, 44.05]

24.01 [24.00, 43.68]

AUClast (ng h/mL)

3.24 (0.81)

9.60 (6.83)

15.47 (5.48)

7697.12 (3930.52)

12497.57 (3537.45)

25394.42 (12912.41)

AUCHD (ng h/mL)

NA

NA

NA

288.52 (119.78)

458.82 (226.88)

784.87 (205.39)

CL/F (L/hr)

554.41 (37.86)

558.27 (252.14)

645.73 (161.19)

NA

NA

NA

CLHD (mL/hr)

NA

NA

NA

5.14 (1.87)

6.41 (3.43)

6.92 (1.30)

Drug excreted by dialysis (%)*

NA

NA

NA

0.06 (0.04)

0.05 (0.02)

0.04 (0.01)

  1. Data presented mean (SD) except Tmax, median [min, max]; Cmax, peak plasma concentration; Tmax, time to Cmax; AUC, area under the plasma concentration–time curve; CL/F, oral plasma clearance; CLHD, dialysis clearance; NA, not applicable; *amount excreted of oseltamivir carboxylate / administered oseltamivir.