Dose selection method for pharmacokinetic study in hemodialysis patients using a subpharmacological dose: oseltamivir as a model drug

Table 3 Dose-normalized C _max and AUC _last following a single oral administration of 2.5, 5, and 10 mg of oseltamivir

Parameter	Oseltamivir			P-value^*	Oseltamivir carboxylate			P-value^*
Parameter	Oseltamivir 2.5 mg (n = 4)	Oseltamivir 5 mg (n = 4)	Oseltamivir 10 mg (n = 4)		Oseltamivir 2.5 mg (n = 4)	Oseltamivir 5 mg (n = 4)	Oseltamivir 10 mg (n = 4)
C_max/dose (ng/mL/mg)	0.72 (0.37)	0.94 (0.66)	0.84 (0.30)	0.981	72.43 (38.55)	82.07 (41.31)	59.92 (36.06)	0.926
AUC_last/dose (ng · h/mL/mg)	1.29 (0.33)	1.92 (1.37)	1.55 (0.55)	0.981	3078.9 (1572.2)	2499.5 (707.5)	2539.4 (1291.2)	0.944

Data presented mean (SD); C_max, peak plasma concentration; AUC, area under the plasma concentration–time curve; ^*The Kruskal-Wallis test.

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