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Table 2 Associations $ between different rapid progression of renal function definitions and traditional renal disease risk factors

From: Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study

   With at least three eGFR measurements With at least two eGFR measurements
Years of follow-up Baseline variables RP definition A RP definition B RP definition A RP definition B
OR (95% CI) P OR (95% CI) P OR (95% CI) P OR (95% CI) P
Four Age >50 years 1.90 (1.15-3.14) 0.01 * 2.33 (1.69-3.20) <0.001 2.65 (1.27-5.53) 0.01
Hypertension 1.42 (0.85-2.37) 0.19 1.41 (1.00-1.97) 0.05 1.31 (0.55-3.10) 0.54
Diabetes 1.06 (0.44-2.54) 0.90 0.88 (0.47-1.60) 0.68 0.48 (0.06-3.62) 0.48
Three Age >50 years 1.91 (1.31-2.77) <0.001 2.75 (1.64-4.59) <0.001 2.07 (1.58-2.71) <0.001 2.80 (1.95-4.04) <0.001
Hypertension 1.58 (1.08-2.33) 0.02 1.31 (0.71-2.40) 0.39 1.39 (1.04-1.85) 0.03 0.79 (0.49-1.28) 0.34
Diabetes 0.91 (0.45-1.83) 0.64 1.16 (0.45-3.00) 0.76 0.94 (0.56-1.59) 0.82 1.24 (0.62-2.51) 0.54
Two Age >50 years 2.32 (1.78-3.04) <0.001 2.70 (2.15-3.39) <0.001 2.54 (2.06-3.12) <0.001 2.55 (2.07-3.14) <0.001
Hypertension 1.09 (0.80-1.50) 0.58 1.14 (0.87-1.49) 0.36 0.99 (0.78-1.27) 0.96 1.00 (0.78-1.28) 0.99
  Diabetes 0.92 (0.53-1.61) 0.78 0.73 (0.43-1.23) 0.24 1.14 (0.67-1.95) 0.62 0.98 (0.64-1.51) 0.93
  1. RP definition A: First eGFR >90; average slope during follow-up ≥5 per year; absolute decline ≥5 in two consecutive years; last eGFR <90.
  2. RP definition B: First eGFR >90; absolute decline ≥5 in all years of follow-up; last eGFR <90.
  3. $Results from multivariable logistic regression analysis.
  4. *Insufficient numbers experiencing RP with this definition.