Development of a definition for Rapid Progression (RP) of renal function in HIV-positive persons: the D:A:D study

BMC Nephrology

Table 2 Associations ^$ between different rapid progression of renal function definitions and traditional renal disease risk factors

		With at least three eGFR measurements				With at least two eGFR measurements
Years of follow-up	Baseline variables	RP definition A		RP definition B		RP definition A		RP definition B
Years of follow-up	Baseline variables	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Four	Age >50 years	1.90 (1.15-3.14)	0.01	*		2.33 (1.69-3.20)	<0.001	2.65 (1.27-5.53)	0.01
	Hypertension	1.42 (0.85-2.37)	0.19			1.41 (1.00-1.97)	0.05	1.31 (0.55-3.10)	0.54
	Diabetes	1.06 (0.44-2.54)	0.90			0.88 (0.47-1.60)	0.68	0.48 (0.06-3.62)	0.48
Three	Age >50 years	1.91 (1.31-2.77)	<0.001	2.75 (1.64-4.59) <0.001		2.07 (1.58-2.71)	<0.001	2.80 (1.95-4.04)	<0.001
	Hypertension	1.58 (1.08-2.33)	0.02	1.31 (0.71-2.40) 0.39		1.39 (1.04-1.85)	0.03	0.79 (0.49-1.28)	0.34
	Diabetes	0.91 (0.45-1.83)	0.64	1.16 (0.45-3.00) 0.76		0.94 (0.56-1.59)	0.82	1.24 (0.62-2.51)	0.54
Two	Age >50 years	2.32 (1.78-3.04)	<0.001	2.70 (2.15-3.39) <0.001		2.54 (2.06-3.12)	<0.001	2.55 (2.07-3.14)	<0.001
Two	Hypertension	1.09 (0.80-1.50)	0.58	1.14 (0.87-1.49) 0.36		0.99 (0.78-1.27)	0.96	1.00 (0.78-1.28)	0.99
	Diabetes	0.92 (0.53-1.61)	0.78	0.73 (0.43-1.23) 0.24		1.14 (0.67-1.95)	0.62	0.98 (0.64-1.51)	0.93

RP definition A: First eGFR >90; average slope during follow-up ≥5 per year; absolute decline ≥5 in two consecutive years; last eGFR <90.
RP definition B: First eGFR >90; absolute decline ≥5 in all years of follow-up; last eGFR <90.
^$Results from multivariable logistic regression analysis.
*Insufficient numbers experiencing RP with this definition.

ISSN: 1471-2369