Figure 6

Proteinuria in Clic4 null mice. A. Total protein to creatinine ratio in urine from young adult male mice. WT: 0.296 ± 0.030 mg/mg (n = 17); Clic4 null: 1.074 ± 0.182 mg/mg (n = 17), P = 0.00019. B. Urine albumin to creatinine ratio using a different set of male mice. WT: 34.1 ± 10.7 μg/mg (n = 5); Clic4 null 69.8 ± 28.5 μg/mg (n = 5) (P = 0.030). C. Fractional excretion of β2 microglobulin in the same mice used in panel B. WT: 0.37% ± 0.11 (n = 5) Clic4 null: 0.21% ± .04 (n = 5) (n.s.).