Figure 8

Both Angiotensin Receptor Blocker (ARB) and hydralazine afford similar attenuation of injury in the contralateral kidney of db RAS. A. Representative histological images of contralateral kidney of db/db mice undergoing RAS or sham surgery and treated with either ARB or hydralazine (Hyd) as stained with periodic acid schiff (PAS), fibronectin (FN), Masson’s Trichrome, and anti F4/80 antibody. PAS images are taken at 400× magnification while fibronectin, trichrome and F4/80 images are taken at 200× magnification. B. Both ARB and hydralazine attenuated mesangial matrix expansion to a similar degree in the contralateral kidney of db mice with RAS. C. Both ARB and hydralazine attenuated development of interstitial fibrosis to a similar degree in the contralateral kidney of db mice with RAS. D. Both ARB and hydralazine reduced renal macrophage infiltration into the contralateral kidney of db RAS mice. E. ARB but not hydralazine attenuated albuminuria in the db RAS mice. * p < 0.05, ** p < 0.01.