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Table 3 Bone histomorphometry data

From: Mineral bone disorder in chronic kidney disease: head-to-head comparison of the 5/6 nephrectomy and adenine models

Parameter

Control

AIRF

5/6Nx

(n = 10)

(n = 10)

(n = 10)

BV/TV (%)

25.0 ± 4.8

31.1 ± 6.7

30.3 ± 3.7

TbN (n/mm)

3.7 ± 0.6

3.3 ± 0.7

4.7 ± 0.5a,b

Tb.SP (μm)

208.8 ± 48.2

223.6 ± 95.6

147.6 ± 26.5b

Tb.Th (μm)

67.1 ± 5.5

93.4 ± 8.8a

63.8 ± 4.0b

ObS/BS (%)

5.4 ± 3.0

25.3 ± 6.2a

5.8 ± 2.3b

OV/BV (%)

0.45(0.14-0.56)

1.46(0.54-3.78)a

0.28(0.20-0.77)b

O.Th (μm)

1.7 ± 0.4

2.6 ± 1.3

1.5 ± 0.2b

OS/BS (%)

1.6(1.2-2.1)

30.3(18.8-40.5)a

6.1(5.1-13.9)b

OcS/BS (%)

1.9 ± 1.1

7.4 ± 2.8a

3.2 ± 1.5b

ES/BS (%)

9.1 ± 1.9

24.5 ± 6.3a

12.3 ± 5.1b

MS/BS (%)

6.0(3.7-9.1)

10.3(7.1-14.3)

2.4(0.8-5.3)a,b

MAR (μm/day)

0.8 ± 0.4

1.0 ± 0.7

0.8 ± 0.2b

BFR (μm3 /μm2 per day)

0.03(0.01-0.05)

0.14(0.01-0.22)

0.02(0.01-0.03)b

MLT (d)

3.6(1.6-8.1)

8.4(1.4-136.0)a

4.6(3.4-14.8)b

  1. Data expressed as mean ± SD or median (min-max).
  2. BV/TV, Bone volume/trabecular volume; TbN, Trabecular number; Tb.SP, Trabecular separation; TbTh, Trabecular thickness; Obs/BS, Osteoblast surface/bone surface; OV/BV, Osteoid volume/bone volume; O.Th, Osteoid thickness; OS/BS, Osteoid surface/bone surface; OcS/BS, Osteoclast surface/bone surface; ES/BS, Eroded surface/bone surface; MS/BS, Mineralization surface/bone surface; MAR, Mineral apposition rate; BFR, Bone formation rate; MLT, Mineralization lag time.
  3. ap < 0.05 vs. Control; bvs. AIRF.