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Table 3 Bone histomorphometry data

From: Mineral bone disorder in chronic kidney disease: head-to-head comparison of the 5/6 nephrectomy and adenine models

Parameter Control AIRF 5/6Nx
(n = 10) (n = 10) (n = 10)
BV/TV (%) 25.0 ± 4.8 31.1 ± 6.7 30.3 ± 3.7
TbN (n/mm) 3.7 ± 0.6 3.3 ± 0.7 4.7 ± 0.5a,b
Tb.SP (μm) 208.8 ± 48.2 223.6 ± 95.6 147.6 ± 26.5b
Tb.Th (μm) 67.1 ± 5.5 93.4 ± 8.8a 63.8 ± 4.0b
ObS/BS (%) 5.4 ± 3.0 25.3 ± 6.2a 5.8 ± 2.3b
OV/BV (%) 0.45(0.14-0.56) 1.46(0.54-3.78)a 0.28(0.20-0.77)b
O.Th (μm) 1.7 ± 0.4 2.6 ± 1.3 1.5 ± 0.2b
OS/BS (%) 1.6(1.2-2.1) 30.3(18.8-40.5)a 6.1(5.1-13.9)b
OcS/BS (%) 1.9 ± 1.1 7.4 ± 2.8a 3.2 ± 1.5b
ES/BS (%) 9.1 ± 1.9 24.5 ± 6.3a 12.3 ± 5.1b
MS/BS (%) 6.0(3.7-9.1) 10.3(7.1-14.3) 2.4(0.8-5.3)a,b
MAR (μm/day) 0.8 ± 0.4 1.0 ± 0.7 0.8 ± 0.2b
BFR (μm3 /μm2 per day) 0.03(0.01-0.05) 0.14(0.01-0.22) 0.02(0.01-0.03)b
MLT (d) 3.6(1.6-8.1) 8.4(1.4-136.0)a 4.6(3.4-14.8)b
  1. Data expressed as mean ± SD or median (min-max).
  2. BV/TV, Bone volume/trabecular volume; TbN, Trabecular number; Tb.SP, Trabecular separation; TbTh, Trabecular thickness; Obs/BS, Osteoblast surface/bone surface; OV/BV, Osteoid volume/bone volume; O.Th, Osteoid thickness; OS/BS, Osteoid surface/bone surface; OcS/BS, Osteoclast surface/bone surface; ES/BS, Eroded surface/bone surface; MS/BS, Mineralization surface/bone surface; MAR, Mineral apposition rate; BFR, Bone formation rate; MLT, Mineralization lag time.
  3. ap < 0.05 vs. Control; bvs. AIRF.