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Table 1 Baseline characteristics of patients with idiopathic membranous nephropathy and nephrotic syndrome, classified according to fractional excretion of IgG

From: Fractional excretion of IgG in idiopathic membranous nephropathy with nephrotic syndrome: a predictive marker of risk and drug responsiveness

 

All patients

FE-IgG

 

P-value

  

Low (<0.020)

High (≥0.020)

 

No. of patients

84

40

44

 

Age (years)

55 ± 16

52 ± 15

58 ± 17

0.07

Sex (M/F)

50/34

20/19

30/15

0.18

eGFR (ml/min/1.73 m2)

72 ± 26

88 ± 20

58 ± 23

< 0.001

eGFR < 60 ml/min/1.73 m2

29 (34%)

5 (13%)

24 (53%)

<0.001

BP ≥140/90 mmHg

45 (54%)

13 (34%)

32 (71%)

0.001

Serum albumin g/L

23 ± 6

25 ± 5

22 ± 6

0.02

ACR mg/mmol

373 ± 256

243 ± 278

486 ± 177

< 0.001

FE IgG

0.052 ± 0.063

0.009 ± 0.005

0.090 ± 0.066

< 0.001

FE α1m

0.371 ± 0.409

0.124 ± 0.106

0.601 ± 0.447

< 0.001

GGS (%)

10 ± 14

6 ± 10

13 ± 17

0.02

TIF score

1.3 ± 1.3

0.7 ± 0.7

1.2 ± 0.7

0.08

Follow-up (months)

86 ± 50

98 ± 51

77 ± 48

0.055

ACE inhibitors treatment

50 (60%)

26 (65%)

24 (55%)

0.27

  1. P-values are for the difference between the FE-IgG subgroups.
  2. ACE: Angiotensin converting enzyme; eGFR: estimated GFR; BP: blood pressure; ACR: urinary albumin/creatinine ratio; FE IgG: fractional excretion of IgG; FE α1m: fractional excretion of α1-microglobulin; GGS: global glomerular sclerosis; TIF: tubulo-interstitial fibrosis.
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BMC Nephrology

ISSN: 1471-2369

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