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Table 2 Characteristics of receiver operating curves (ROC) for the investigated biomarkers: area under the curves (AUC), cut-off levels, sensitivity, specificity and likelihood ratio for predicting kidney failure (n 84) and No remission (n 70) in idiopathic membranous nephropathy patients with nephrotic syndrome

From: Fractional excretion of IgG in idiopathic membranous nephropathy with nephrotic syndrome: a predictive marker of risk and drug responsiveness

Biomarkers

AUC

p-value

Cut-off

Sensitivity %

Specificity %

Likelihood ratio

Prediction of kidney failure

eGFR

0.27

0.003

60

32

25

0.42

FE IgG

0.77

< 0.001

0.020

95

59

2.3

ACR

0.75

< 0.001

4000

84

56

1.9

FE α1m

0.76

< 0.001

0.240

84

60

2.1

High FE IgG and FE α1m

0.784

<0.001

0.02 + 0.24

84

68

2.6

Prediction of no remission

eGFR

0.26

0.001

60

41

11

0.46

FE IgG

0.82

< 0.001

0.020

91

72

3.3

ACR

0.73

< 0.001

4000

76

69

2.5

FE α1m

0.76

< 0.001

0.240

85

67

2.6

High FE IgG and FE α1m

0.83

<0.001

0.02 + 0.24

82

78

3.7

  1. eGFR: estimated GFR (ml/min/1.73 m2); FE IgG: fractional excretion of IgG; ACR: urinary albumin/creatinine ratio; FE α1m: fractional excretion of α1-microglobulin.