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Table 4 Clinical, proteinuric and histologic parameters of 35 idiopathic membranous nephropathy patients with nephrotic syndrome not treated with immunosuppressive drugs and 37 others treated with combined steroids and cyclophosphamide

From: Fractional excretion of IgG in idiopathic membranous nephropathy with nephrotic syndrome: a predictive marker of risk and drug responsiveness

 

Untreated

Treated

p-value

No. of patients

35

37

 

Age (years)

53 ± 17

56 ± 16

0.65, ns

Sex (M/F)

16/19

26/11

0.034

Baseline eGFR ml/min/1.73 m2

77 ± 27

69 ± 25

0.19, ns

eGFR < 60 ml/min/1.73 m2

34%

32%

0.8, ns

BP ≥140/90 mmHg

52%

51%

0.89, ns

ACR mg/mmol

350 ± 242

379 ± 185

0.57, ns

FE IgG

0.040 ± 0.055

0.067 ± 0.069

0.07, ns

FE α1m

0.325 ± 0.382

0.435 ± 0.411

0.24, ns

GGS (%)

7.7 ± 10.7

11.3 ± 17.7

0.30, ns

TIF score

1.0 ± 0.9

1.4 ± 1.3

0.19, ns

Time to reach ESRD (months)

55 ± 29

90 ± 46

0.07, ns

  1. Legend: eGFR: estimated GFR; ESRD: end stage renal disease; BP: blood pressure; ACR: urinary albumin/creatinine ratio; FE IgG: fractional excretion of IgG; FE α1m: fractional excretion of α1-microglobulin; GGS: global glomerular sclerosis; TIF: tubulo-interstitial fibrosis (0 absent, 1 focal, 2 diffuse), ns = non-significant.