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Table 1 Anti-depressant dosing in popular drug prescribing references

From: Higher anti-depressant dose and major adverse outcomes in moderate chronic kidney disease: a retrospective population-based study

 

Higher dose (mg/day)*

Lower dose (mg/day)*

UpToDate recommendation [19]-[21]]

Compendium of pharmaceuticals and specialties [22]-[24]]

Systematic review [6]]

Paroxetine

> 20

≤ 20

• 20 – 50 mg/day

• 20 – 50 mg/day

• 20 – 50 mg/day

• Reduce by 50% with CrCl < 30 ml/min

• Initiate at 10 mg/day with CrCl < 40 ml/min

• Initiate at 10 mg/day with eGFR < 60 ml/min

Mirtazapine

> 20

≤ 20

• 15 – 45 mg/day

• 15 – 45 mg/day

• 15 – 45 mg/day

• Use with caution with CrCl < 40 ml/min

• Use with caution

• Use with caution

• Initiate at 15 mg/day with eGFR < 30 ml/min

Venlafaxine

> 37.5

≤ 37.5

• 75 – 225 mg/day

• 75 – 225 mg/day

• 75 – 225 mg/day

• Reduce by 25 – 50% with CrCl 10 – 70 ml/min

• Reduce by 25 – 50% with GFR 10–70 ml/min

• Reduce to 37.5 mg/day with eGFR < 30 ml/min

• Initiate at 37.5 mg/day

  1. *As defined in this study.
  2. Abbreviations: CrCl Creatinine clearance, eGFR estimated glomerular filtration rate.