Table 1 PTH (pg/mL) and Ca (mg/dL) levels in 5/6 Nx repeat-dose study
From: Comparison of AMG 416 and cinacalcet in rodent models of uremia
PTH | ||||
|---|---|---|---|---|
Week | Hour post dosing | Cinacalcet | AMG 416 | Vehicle |
Week 1 | 6 hr | 128 ± 44 | 30 ± 6 | 758 ± 191 |
16 hr | 312 ± 72 | 155 ± 30 | 472 ± 126 | |
Week 4 | 6 hr | 115 ± 73 | 18 ± 4 | 451 ± 162 |
16 hr | 700 ± 315 | 66 ± 18 | 357 ± 69 | |
Calcium | ||||
Week | Hour post dosing | Cinacalcet | AMG 416 | Vehicle |
Week 1 | 6 hr | 8.9 ± 0.3 | 8.0 ± 0.3 | 10.4 ± 0.3 |
16 hr | 10.0 ± 0.3 | 8.5 ± 0.3 | 11.0 ± 0.3 | |
Week 4 | 6 hr | 9.3 ± 0.4 | 8.9 ± 0.3 | 10.7 ± 0.2 |
16 hr | 10.3 ± 0.5 | 9.2 ± 0.4 | 11.1 ± 0.2 | |