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Table 5 Cox proportional hazard multivariate models of time to first cardiovascular event (number of events = 25)

From: Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease

Model

24 h urinary excretion of p-cresyl sulfate

Hazard ratio per 100 μmol increase (95% confidence interval)

P

1. Unadjusted

1.112 (1.041 – 1.187)

0.002

2. Prior cardiovascular disease and diabetes mellitus

1.083 (1.005 – 1.167)

0.04

3. eGFR and 24 h proteinuria (Ln)

1.120 (1.042 – 1.205)

0.002

4. Creatinine and age

1.120 (1.040 – 1.206)

0.003

5. Albumine and body mass index

1.078 (1.014 – 1.146)

0.02

6. Systolic blood pressure and parathormone (Ln)

1.106 (1.038 – 1.179)

0.002

7. Hemoglobin and C-reactive protein (Ln)*

1.112 (1.041 – 1.187)

0.002

  1. *Hemoglobin was entered as time-dependent covariate.