Proteinuria and hematuria are associated with acute kidney injury and mortality in critically ill patients: a retrospective observational study

Table 5 Interaction between acute kidney injury and hematuria on the risk of mortality

	No hematuria		Hematuria
	N with/without outcome	OR (95% CI)	N with/without outcome	OR (95% CI)	OR for proteinuria within strata of AKI status
No AKI	65/144	1 (Reference)	76/117	1.44 (0.954–2.171)	1.44 (0.954–2.171)
AKI	278/179	3.44 ( 2.430–4.872)^†	689/335	4.56 (3.306–6.279)^†	1.32 (1.054–1.665)*
OR for AKI within strata of hematuria status		3.44 ( 2.430–4.872)^†		3.17 (2.306–4.347)^†

Measure of interaction on additive scale: RERI (95% CI) = 0.68 (−0.543–1.665); AP (95% CI) = 0.15 (−0.118–0.347); SI (95% CI) = 1.23 (0.864–1.853).
*P < 0.05; ^† P < 0.001.
OR, odds ratio; CI, confidence interval; AKI, acute kidney injury; RERI, relative excess risk due to interaction; AP, attributable proportion; SI, synergy index.

ISSN: 1471-2369