Skip to main content

Table 2 The cross-sectional association between B12 (OR per 1SD increase log Vitamin B12) and prevalent albuminuria and RKF at Offspring Examination 6

From: The association between vitamin B12, albuminuria and reduced kidney function: an observational cohort study

   

Model 1

Model 2

Model 3

 

n

Events (%)

OR

CI

p-value

OR

CI

p-value

OR

CI

p-value

Entire Cohort

          

Albuminuria

2965

523 (17.6)

1.25

0.98-1.60

0.07

1.25

0.97-1.61

0.08

1.44

1.10-1.87

0.008

RKF

3451

319 (9.2)

0.99

0.72-1.35

0.94

0.98

0.72-1.35

0.92

1.83

1.30-2.59

<0.001

Stratified analysis: Albuminuria*

          

Homocysteine < median

1511

228 (15.1)

1.28

0.87-1.88

0.21

1.29

0.87-1.91

0.21

1.27

0.85-1.90

0.24

Homocysteine ≥ median

1454

295 (20.3)

1.45

1.03-2.03

0.03

1.41

0.99-2.01

0.06

1.57

1.10-2.26

0.01

Stratified analysis: RKF*

          

Homocysteine < median

1722

70 (4.1)

0.90

0.47-1.75

0.76

0.92

0.47-1.78

0.80

1.22

0.62-2.41

0.56

Homocysteine ≥ median

1729

249 (14.4)

1.62

1.10-2.37

0.01

1.57

1.06-2.31

0.02

2.17

1.44-3.26

<0.001

  1. Model 1: Age- and sex- adjusted.
  2. Model 2: Multivariable-adjusted: Albuminuria - systolic blood pressure, HDLc, smoking status, hypertension treatment and diabetes.
  3. RKF: diabetes, hypertension and dipstick proteinuria.
  4. Model 3: Multivariable-adjusted + baseline log homocysteine.
  5. *Stratified by the median homocysteine levels (9.08 μmol/L).
  6. p-value <0.001 for comparison.