From: Sex steroids do not affect shigatoxin cytotoxicity on human renal tubular or glomerular cells
HPT | Dose | [Stx-1] gm/L | Stx alone (% survival) | Day 1 (% survival) | Day 2 (% survival) | Day 7 (% survival) |
---|---|---|---|---|---|---|
Estradiol | 1 μM | -5 | 54 ± 4 | 49 ± 4 | 50 ± 4 | 46 ± 5 |
1 μM | -8 | 90 ± 7 | 81 ± 7 | 83 ± 7 | 84 ± 9 | |
1 μM | -11 | 102 ± 8 | 97 ± 5 | 99 ± 7 | 107 ± 7 | |
100 pM | -5 | 54 ± 4 | 49 ± 4 | 60 ± 4 | 49 ± 6 | |
100 pM | -8 | 90 ± 7 | 95 ± 8 | 90 ± 7 | 87 ± 8 | |
100 pM | -11 | 102 ± 8 | 97 ± 6 | 103 ± 5 | 92 ± 9 | |
Progesterone | 1 μM | -5 | 54 ± 4 | 56 ± 4 | 52 ± 3 | 60 ± 5 |
1 μM | -8 | 90 ± 7 | 99 ± 9 | 81 ± 7 | 91 ± 9 | |
1 μM | -11 | 102 ± 8 | 107 ± 8 | 101 ± 5 | 106 ± 8 | |
30 nM | -5 | 54 ± 4 | 50 ± 6 | 52 ± 3 | 54 ± 4 | |
30 nM | -8 | 90 ± 7 | 86 ± 4 | 83 ± 5 | 90 ± 5 | |
30 nM | -11 | 102 ± 8 | 97 ± 7 | 105 ± 5 | 92 ± 7 | |
Testosterone | 1 μM | -5 | 54 ± 4 | 57 ± 3 | 49 ± 4 | 58 ± 5 |
1 μM | -8 | 90 ± 7 | 92 ± 7 | 89 ± 5 | 91 ± 8 | |
1 μM | -11 | 102 ± 8 | 94 ± 5 | 97 ± 6 | 100 ± 6 | |
30 nM | -5 | 54 ± 4 | 51 ± 4 | 64 ± 7 | 57 ± 3 | |
30 nM | -8 | 90 ± 7 | 98 ± 8 | 97 ± 7 | 85 ± 5 | |
30 nM | -11 | 102 ± 8 | 109 ± 10 | 102 ± 6 | 103 ± 7 |