Figure 3

M680I Missense Mutation. Illustration of the unspliced MEFV gene locus with exons 1–10 depicted (a), the spliced mRNA transcript revealing exon 2 and exon 10 and their respective codon number identifying where the nine most common mutations for FMF have been identified (b); a diagram illustrating the derivation of the M680I mutation from exon 10 with the amino acid methionine (wild-type) substituted with isoleucine at codon 680 (c).