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Figure 1 | BMC Nephrology

Figure 1

From: Effects of chemokines on proliferation and apoptosis of human mesangial cells

Figure 1

Dose- and time- dependent effect of SLC/CCL21 on proliferation of human MC. (A) Incubation of human MC with various concentrations of SLC/CCL21 (10 ng/ml, 50 ng/ml, 100 ng/ml, 250 ng/ml) induces proliferation of MC in a dose-dependent manner. (B) Time-course stimulation of MC with SLC/CCL21 for various time intervals (24 h, 48 h, 72 h). Cell proliferation was analyzed with the MTT assay as described in Methods. Cells growing under standard conditions served as control. Changes in proliferative activity are given as relative values to the respective controls. Each bar represents a mean ± SEM of 7 parallel incubations for each condition. Statistically significant differences to the control are depicted with * = p < 0.05 and ** = p < 0.01, resp. Comparable results were obtained in three series of independent experiments.

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