Hypothyroidism attenuates protein tyrosine nitration, oxidative stress and renal damage induced by ischemia and reperfusion: effect unrelated to antioxidant enzymes activities

Table 6 Effect of experimental hypothyroidism on antioxidant enzymes activities.

Ref.	Specie	MHI	Change in antioxidant enzymes
61	Rat	MMI	↑ MnSOD and CAT and ↔ Cu, ZnSOD in brown adipose tissue.
62	Rat	PTU	In liver mitochondria: ↑ Total and Cu, ZnSOD, ↔ MnSOD, ↓ CAT. ↑ Total and Se-independent and Se-dependent GPx
63	Rat	PTU	↓ SOD and ↔ CAT in heart.
64	Rat	MMI	↑ GPx, ↔ CAT, and total SOD in heart.
65	Rat	PTU	↓ SOD and CAT and ↑ GPx in testis.
66	Rat	PTU	In brain: ↑ Total and MnSOD, CAT, total and Se-dependent GPx. ↓ Se-independent GPx, and GR.
55	Rat	MMI	In cerebral cortex: ↑ Total SOD, Cu, ZnSOD, and GPx, and ↓ MnSOD. ↔ CAT.
67	Rat	Na¹³¹I	↓ SOD, ↔ CAT, and ↑ GPx in kidney. ↓ Plasma GPx.
47	Rat	PTU	Cu, ZnSOD ↔ in extensor digitorum longus and soleus muscles, ↑ heart, and ↓ liver. GPx ↔ in soleus muscle and liver ↑ extensor digitorum longus muscle and heart.
68	Rat	MMI	GPx ↑ in gastrocnemius muscle and heart, and ↔ in liver. GR in ↔ heart, gastrocnemius muscle, and liver.

Ref. = reference, MHI = Method of hypothyroidism induction, PTU = 6-n-propyl-2-thiouracil, MMI = methimazole, ↑ = increase, ↓ = decrease, ↔ = without change, SOD = superoxide dismutase, MnSOD = manganese-dependent superoxide dismutase, Cu, ZnSOD = copper,zinc-dependent superoxide dismutase, Se = selenium, GPx = Glutathione peroxidase, GR = glutathione reductase, CAT = catalase.

ISSN: 1471-2369