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Table 2 Distribution of pairs of relatives in 72 IgAN families according to genetic relationship and IgAN.

From: The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait

 

IgA Nephropathy status

Relationship

A/A

A/P

A/N

N/N

Total pair

Spousal

0

2

25

35

62

Parent-offspring

20

19

147

211

397

Sibling

44

32

168

185

429

Half-sibling

0

0

4

0

4

Granparental

0

4

5

89

98

Avuncular

8

22

170

382

582

Cousin

5

6

40

238

289

Other

17

9

141

545

712

Total Pairs

94

94

700

1685

2573

  1. (A) affected subjects with biopsy-proven disease; (P) subjects probably affected by IgAN when persistent microscopic hematuria without biopsy-proven glomerulonephritis, or chronic renal insufficiency or ESRD treated with hemo or peritoneal dialysis, or renal transplantation after biopsy-proven IgAN or unknown glomerulonephritis, or death for chronic uremia, occurred; (N) non-affected subjects in the absence of urinary abnormalities.