Improvement of renal function with treatment | P | ||
---|---|---|---|
YES (n = 6) | NO (n = 9) | ||
Serum creatinine (mg/dl) | 3.1 | 5.2 | 0.03 |
Urine protein (g/24 h) | 2.4 | 1.7 | NS |
TGF-β1 urine levels (ng/24 h) | 376 | 930 | 0.001 |
Glomeruli with crescents (%) | 56% | 79% | 0.03 |
Cellular crescents (%) | 37% | 50% | NS |
Fibrocellular crescents (%) | 44% | 31% | NS |
Fibrotic crescents (%) | 15% | 20% | NS |
Bowman's capsule rupture and glomerular necrosis [# of pts (%)] | 1/6 (17%) | 6/9 (67%) | <0.05 |
Interstitial inflammation (# of pts) | Mild (n = 2) Severe (n = 4) | Mild (n = 2) Severe (n = 7) | NS |
Interstitial fibrosis (# of pts) | Mild (n = 5) Severe (n = 1) | Mild (n = 4) Severe (n = 5) | NS |
TGF-β1 immunostaining (% stained points) | 27 ± 8 | 25 ± 12 | NS |