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Table 2 Clinical and histological features of patients with or without improvement of renal function with immunosuppressive therapy.

From: Urinary Transforming Growth Factor-beta 1 as a marker of response to immunosuppressive treatment, in patients with crescentic nephritis

 

Improvement of renal function with treatment

P

 

YES (n = 6)

NO (n = 9)

 

Serum creatinine (mg/dl)

3.1

5.2

0.03

Urine protein (g/24 h)

2.4

1.7

NS

TGF-β1 urine levels (ng/24 h)

376

930

0.001

Glomeruli with crescents (%)

56%

79%

0.03

Cellular crescents (%)

37%

50%

NS

Fibrocellular crescents (%)

44%

31%

NS

Fibrotic crescents (%)

15%

20%

NS

Bowman's capsule rupture and glomerular necrosis [# of pts (%)]

1/6 (17%)

6/9 (67%)

<0.05

Interstitial inflammation (# of pts)

Mild (n = 2)

Severe (n = 4)

Mild (n = 2)

Severe (n = 7)

NS

Interstitial fibrosis (# of pts)

Mild (n = 5)

Severe (n = 1)

Mild (n = 4)

Severe (n = 5)

NS

TGF-β1 immunostaining (% stained points)

27 ± 8

25 ± 12

NS