Table 3 Top 50 genes upregulated in the E18.5 control kidney when compared to the Lim1 conditional mutant kidney.

Solute carrier family 34, member 1

20505

Slc34a1

63.47

4.0

78.05

Uromodulin

22242

Umod

58.19

4.0

61.91

HL,DT

[54]

Calbindin 3

12309

Calb3

45.16

4.0

11.13

DT

[55]

Glutathione S-transferase, alpha 2

14858

Gsta2

41.30

4.0

31.73

PT

[56]

Hydroxyacid oxidase 3

56185

Hao3

40.21

4.0

24.19

Nephrosis 2 homolog, podocin

170484

Nphs2

39.83

2.0

71.88

Pod

[57]

Kidney-specific membrane protein

57394

Tmem27

37.83

4.0

36.97

DN,DT, PT, UT

[14]

MGC37245

233799

MGC37245

36.09

Cytochrome P450, family 2, subfamily j, polypeptide 5

13109

Cyp2j5

36.03

4.0

15.60

FXYD domain-containing ion transport regulator 2

11936

Fxyd2

35.57

4.0

69.12

PT, HL

[58]

Klotho

16591

Kl

35.49

4.0

53.50

PT

[59]

Kidney androgen regulated protein

16483

Kap

35.36

4.0

40.76

PT

[60]

Hydroxysteroid dehydrogenase-4, delta<5>-3-beta

15495

Hsd3b4

34.28

4.0

50.43

Fructose bisphosphatase 1

14121

Fbp1

32.04

4.0

18.74

DN,DT, PT,UT

[61]

Gamma-glutamyltransferase 1

14598

Ggt1

30.65

4.0

17.68

PT

[62]

Solute carrier family 5, member 8

216225

Slc5a8

29.22

13.49

Solute carrier family 26, member 1

231583

Slc26a1

27.27

3.0

14.30

PT

[63]

Low density lipoprotein receptor-related protein 2

14725

Lrp2

25.73

51.68

PT,Gl

[64]

Aldolase 2, B isoform

230163

Aldo2

23.80

4.0

37.02

PT

[65]

Kynurenine aminotransferase II

23923

Kat2

23.35

4.0

67.29

Cubilin

65969

Cubn

22.94

3.0

5.18

PT

[66]

Solute carrier family 12, member 1

20495

Slc12a1

22.45

4.0

74.20

HL

[67]

RIKEN cDNA D630043A20 gene

207151

Slc22a19

21.95

4.0

81.09

RIKEN cDNA 0610038O04 gene

75396

0610038004Rik

21.91

Phenylalanine hydroxylase

18478

Pah

21.25

4.0

28.04

PT

[68]

Sulfotransferase family 1D, member 1

53315

Sult1d1

20.47

10.49

Betaine-homocysteine methyltransferase 2

64918

Bhmt2

20.26

2.5

5.80

PT

[69]

Serine (or cysteine) proteinase inhibitor, clade A, member 6

12401

Serpina6

19.94

0.5

2.56

Glycine amidinotransferase

67092

Gatm

19.69

4.0

6.83

Fatty acid binding protein 3

14077

Fabp3

19.60

2.0

4.22

RIKEN cDNA 9130022A01 gene

100061

9130022A01Rik

18.71

4.0

UDP-glucuronosyltransferase 1 family, member 2

22236

Ugt1a2

18.42

4.0

Amnionless

93835

Amn

17.98

3.0

4.01

PT,DT

[14]

Cytochrome P450, family 27, subfamily b, polypeptide 1

13115

Cyp27b1

17.91

0.5

98.60

PT

[70]

Potassium inwardly-rectifying channel, subfamily J, member 15

16516

Kcnj15

17.69

43.57

RT

[70]

Claudin 2

12738

Cldn2

17.10

4.0

8.61

PT

[71]

RIKEN cDNA 2010002A20 gene

66601

2010002A20Rik

16.99

4.0

20.30

Defensin beta 1

13214

Defb1

16.78

4.0

34.83

CT,HL

[72]

Kidney-derived aspartic protease-like protein

16541

Kdap

16.76

4.0

38.24

PT

[73]

Serine protease inhibitor, Kazal type 3

20730

Spink3

16.30

4.0

1.13

Hepatic nuclear factor 4

15378

Hnf4

16.20

3.5

5.37

UD,Gl,RV

[74]

Solute carrier family 22, member 6

18399

Slc22a6

15.71

2.5

26.67

DN,PT,Gl

[14]

PDZ domain containing 1

59020

Pdzk1

15.49

4.0

33.70

PT

[75]

Kallikrein 6

16612

Klk6

15.46

4.0

14.16

UT

[76]

RIKEN cDNA 1300013J15 gene

67473

1300013J15Rik

15.36

4.0

32.54

BB738659

BB738659

15.22

Alanyl aminopeptidase

16790

Anpep

14.96

2.5

9.70

PT

[77]

Meprin 1 alpha

17287

Mep1a

14.77

3.0

59.06

Argininosuccinate synthetase 1

11898

Ass1

14.26

4.0

35.65

PT

[78]

Meprin 1 beta

17288

Mep1b

14.13

4.0

2.00