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Table 3 Top 50 genes upregulated in the E18.5 control kidney when compared to the Lim1 conditional mutant kidney.

From: Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice

Gene Name Locus Link Symbol Fold Change GNF 2.0 SOURCE (%) Nephron -specific Reference
Solute carrier family 34, member 1 20505 Slc34a1 63.47 4.0 78.05   
Uromodulin 22242 Umod 58.19 4.0 61.91 HL,DT [54]
Calbindin 3 12309 Calb3 45.16 4.0 11.13 DT [55]
Glutathione S-transferase, alpha 2 14858 Gsta2 41.30 4.0 31.73 PT [56]
Hydroxyacid oxidase 3 56185 Hao3 40.21 4.0 24.19   
Nephrosis 2 homolog, podocin 170484 Nphs2 39.83 2.0 71.88 Pod [57]
Kidney-specific membrane protein 57394 Tmem27 37.83 4.0 36.97 DN,DT, PT, UT [14]
MGC37245 233799 MGC37245 36.09     
Cytochrome P450, family 2, subfamily j, polypeptide 5 13109 Cyp2j5 36.03 4.0 15.60   
FXYD domain-containing ion transport regulator 2 11936 Fxyd2 35.57 4.0 69.12 PT, HL [58]
Klotho 16591 Kl 35.49 4.0 53.50 PT [59]
Kidney androgen regulated protein 16483 Kap 35.36 4.0 40.76 PT [60]
Hydroxysteroid dehydrogenase-4, delta<5>-3-beta 15495 Hsd3b4 34.28 4.0 50.43   
Fructose bisphosphatase 1 14121 Fbp1 32.04 4.0 18.74 DN,DT, PT,UT [61]
Gamma-glutamyltransferase 1 14598 Ggt1 30.65 4.0 17.68 PT [62]
Solute carrier family 5, member 8 216225 Slc5a8 29.22   13.49   
Solute carrier family 26, member 1 231583 Slc26a1 27.27 3.0 14.30 PT [63]
Low density lipoprotein receptor-related protein 2 14725 Lrp2 25.73   51.68 PT,Gl [64]
Aldolase 2, B isoform 230163 Aldo2 23.80 4.0 37.02 PT [65]
Kynurenine aminotransferase II 23923 Kat2 23.35 4.0 67.29   
Cubilin 65969 Cubn 22.94 3.0 5.18 PT [66]
Solute carrier family 12, member 1 20495 Slc12a1 22.45 4.0 74.20 HL [67]
RIKEN cDNA D630043A20 gene 207151 Slc22a19 21.95 4.0 81.09   
RIKEN cDNA 0610038O04 gene 75396 0610038004Rik 21.91     
Phenylalanine hydroxylase 18478 Pah 21.25 4.0 28.04 PT [68]
Sulfotransferase family 1D, member 1 53315 Sult1d1 20.47   10.49   
Betaine-homocysteine methyltransferase 2 64918 Bhmt2 20.26 2.5 5.80 PT [69]
Serine (or cysteine) proteinase inhibitor, clade A, member 6 12401 Serpina6 19.94 0.5 2.56   
Glycine amidinotransferase 67092 Gatm 19.69 4.0 6.83   
Fatty acid binding protein 3 14077 Fabp3 19.60 2.0 4.22   
RIKEN cDNA 9130022A01 gene 100061 9130022A01Rik 18.71 4.0    
UDP-glucuronosyltransferase 1 family, member 2 22236 Ugt1a2 18.42 4.0    
Amnionless 93835 Amn 17.98 3.0 4.01 PT,DT [14]
Cytochrome P450, family 27, subfamily b, polypeptide 1 13115 Cyp27b1 17.91 0.5 98.60 PT [70]
Potassium inwardly-rectifying channel, subfamily J, member 15 16516 Kcnj15 17.69   43.57 RT [70]
Claudin 2 12738 Cldn2 17.10 4.0 8.61 PT [71]
RIKEN cDNA 2010002A20 gene 66601 2010002A20Rik 16.99 4.0 20.30   
Defensin beta 1 13214 Defb1 16.78 4.0 34.83 CT,HL [72]
Kidney-derived aspartic protease-like protein 16541 Kdap 16.76 4.0 38.24 PT [73]
Serine protease inhibitor, Kazal type 3 20730 Spink3 16.30 4.0 1.13   
Hepatic nuclear factor 4 15378 Hnf4 16.20 3.5 5.37 UD,Gl,RV [74]
Solute carrier family 22, member 6 18399 Slc22a6 15.71 2.5 26.67 DN,PT,Gl [14]
PDZ domain containing 1 59020 Pdzk1 15.49 4.0 33.70 PT [75]
Kallikrein 6 16612 Klk6 15.46 4.0 14.16 UT [76]
RIKEN cDNA 1300013J15 gene 67473 1300013J15Rik 15.36 4.0 32.54   
BB738659   BB738659 15.22     
Alanyl aminopeptidase 16790 Anpep 14.96 2.5 9.70 PT [77]
Meprin 1 alpha 17287 Mep1a 14.77 3.0 59.06   
Argininosuccinate synthetase 1 11898 Ass1 14.26 4.0 35.65 PT [78]
Meprin 1 beta 17288 Mep1b 14.13 4.0 2.00   
  1. Abbreviations: CT, collecting tubule; DN, developing nephron; DT: distal convoluted tubule; Gl: glomerulus; HL, loop of Henle; PT, proximal convoluted tubule; Pod, podocyte; RT, renal tubule; RV: renal vesicle; UD, ureteric duct; UT, ureteric tubule.