Skip to main content

Table 4 Top 41 genes upregulated in the E14.5 control kidney when compared to the Lim1 conditional mutant kidney.

From: Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice

Gene Name Locus Link Symbol Fold Change GNF 2.0 SOURCE (%) Nephron -specific Reference
Sulfotransferase family 1D, member 1 53315 Sult1d1 7.22   10.49   
Hydroxyacid oxidase 3 56185 Hao3 7.05 4.0 24.19   
FXYD domain-containing ion transport regulator 2 11936 Fxyd2 5.71 4.0 69.12 PT,HL [58]
Hepatic nuclear factor 4 15378 Hnf4 5.70 3.5 5.37 UD,DG,RV [74]
Kidney-specific membrane protein 57394 Tmem27 4.26 4.0 36.97 DN,DT, PT,UT [14]
Sclerostin domain containing 1 66042 Sostdc1 4.16 3.5 12.36 DT [79]
Lymphocyte antigen 6 complex, locus A 110454 Ly6a 4.05 2.5 7.10   
AW210596 240638 AW210596 3.38 4.0 5.03   
Aldolase 2, B isoform 230163 Aldo2 3.27 4.0 37.02 PT [65]
RIKEN cDNA 9930038N01 gene   9930038N01Rik 3.13     
RIKEN cDNA 0610033E06 gene 112417 0610033E06Rik 3.07 3.5 37.77   
Musashi homolog 2 76626 Msi2h 2.87   1.12   
ATPase, Na+/K+ transporting, beta 1 polypeptide 11931 Atp1b1 2.83 2.5 8.64   
Hairy and enhancer of split 5 15208 Hes5 2.67 0.5 0.00 CB,SB, PT [40]
RIKEN cDNA 1300013J15 gene 67473 1300013J15Rik 2.55 4.0 32.54   
BC013481 245945 BC013481 2.51   1.72   
PDZ domain containing 1 59020 Pdzk1 2.51 4.0 33.70 PT [75]
RIKEN cDNA D630042F21 gene 330428 D630042F21Rik 2.50   70.39   
Glucosaminyl (N-acetyl) transferase 1, core 2 14537 Gcnt1 2.45   5.38   
Dipeptidylpeptidase 4 13482 Dpp4 2.38    PT,DT [80]
Low density lipoprotein receptor-related protein 2 14725 Lrp2 2.37   51.68 PT,Gl [64]
Purkinje cell protein 4 14858 Pcp4 2.35 -2.0 0.00   
Glutathione S-transferase, alpha 2 18546 Gsta2 2.35 4.0 31.73 PT [56]
MGC37245 233799 MGC37245 2.29     
BB427389   BB427389 2.28     
Single-minded 1 20464 Sim1 2.27 2.5 0.00 RT 81
Kidney expressed gene 1 64697 Keg1 2.26 4.0 49.76   
BG064527   BG064527 2.24     
RIKEN cDNA 2610511G16 gene 67500 2610511G16Rik 2.20     
Nephrosis 2 homolog, podocin 170484 Nphs2 2.20 2.0 71.88 Pod 57
Solute carrier family 34, member 1 20505 Slc34a1 2.16 4.0 78.05   
RIKEN cDNA 2700008B19 gene 217026 2700008B19Rik 2.15   1.76   
RIKEN cDNA 6332401O19 gene 319832 6332401O19Rik 2.14   6.71   
RIKEN cDNA 9130423L19 gene 74570 9130423L19Rik 2.11 1.5    
C85657   C85657 2.11     
RIKEN cDNA 5730493B19 gene   5730493B19Rik 2.10     
Fucosyltransferase 9 14348 Fut9 2.10 4.0 3.15   
AU022045   AU022045 2.07     
Jagged 1 16449 Jag1 2.06 1.5 1.20 RV, CB, SB,PT [82]
EH-domain containing 2 259300 Ehd2 2.02   0.00   
RIKEN cDNA 2610510D13 gene 229279 2610510D13Rik 2.01 -0.5    
  1. Abbreviations: CB, comma-shaped body; CT, collecting tubule; DN, developing nephron; DG, developing glomerulus; DT: distal convoluted tubule; Gl: glomerulus; HL, loop of Henle; PT, proximal convoluted tubule; Pod, podocyte; RT, renal tubule; RV: renal vesicle; SB, S-shaped body; UD, ureteric duct; UT, ureteric tubule