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Table 4 Top 41 genes upregulated in the E14.5 control kidney when compared to the Lim1 conditional mutant kidney.

From: Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice

Gene Name

Locus Link

Symbol

Fold Change

GNF 2.0

SOURCE (%)

Nephron -specific

Reference

Sulfotransferase family 1D, member 1

53315

Sult1d1

7.22

 

10.49

  

Hydroxyacid oxidase 3

56185

Hao3

7.05

4.0

24.19

  

FXYD domain-containing ion transport regulator 2

11936

Fxyd2

5.71

4.0

69.12

PT,HL

[58]

Hepatic nuclear factor 4

15378

Hnf4

5.70

3.5

5.37

UD,DG,RV

[74]

Kidney-specific membrane protein

57394

Tmem27

4.26

4.0

36.97

DN,DT, PT,UT

[14]

Sclerostin domain containing 1

66042

Sostdc1

4.16

3.5

12.36

DT

[79]

Lymphocyte antigen 6 complex, locus A

110454

Ly6a

4.05

2.5

7.10

  

AW210596

240638

AW210596

3.38

4.0

5.03

  

Aldolase 2, B isoform

230163

Aldo2

3.27

4.0

37.02

PT

[65]

RIKEN cDNA 9930038N01 gene

 

9930038N01Rik

3.13

    

RIKEN cDNA 0610033E06 gene

112417

0610033E06Rik

3.07

3.5

37.77

  

Musashi homolog 2

76626

Msi2h

2.87

 

1.12

  

ATPase, Na+/K+ transporting, beta 1 polypeptide

11931

Atp1b1

2.83

2.5

8.64

  

Hairy and enhancer of split 5

15208

Hes5

2.67

0.5

0.00

CB,SB, PT

[40]

RIKEN cDNA 1300013J15 gene

67473

1300013J15Rik

2.55

4.0

32.54

  

BC013481

245945

BC013481

2.51

 

1.72

  

PDZ domain containing 1

59020

Pdzk1

2.51

4.0

33.70

PT

[75]

RIKEN cDNA D630042F21 gene

330428

D630042F21Rik

2.50

 

70.39

  

Glucosaminyl (N-acetyl) transferase 1, core 2

14537

Gcnt1

2.45

 

5.38

  

Dipeptidylpeptidase 4

13482

Dpp4

2.38

  

PT,DT

[80]

Low density lipoprotein receptor-related protein 2

14725

Lrp2

2.37

 

51.68

PT,Gl

[64]

Purkinje cell protein 4

14858

Pcp4

2.35

-2.0

0.00

  

Glutathione S-transferase, alpha 2

18546

Gsta2

2.35

4.0

31.73

PT

[56]

MGC37245

233799

MGC37245

2.29

    

BB427389

 

BB427389

2.28

    

Single-minded 1

20464

Sim1

2.27

2.5

0.00

RT

81

Kidney expressed gene 1

64697

Keg1

2.26

4.0

49.76

  

BG064527

 

BG064527

2.24

    

RIKEN cDNA 2610511G16 gene

67500

2610511G16Rik

2.20

    

Nephrosis 2 homolog, podocin

170484

Nphs2

2.20

2.0

71.88

Pod

57

Solute carrier family 34, member 1

20505

Slc34a1

2.16

4.0

78.05

  

RIKEN cDNA 2700008B19 gene

217026

2700008B19Rik

2.15

 

1.76

  

RIKEN cDNA 6332401O19 gene

319832

6332401O19Rik

2.14

 

6.71

  

RIKEN cDNA 9130423L19 gene

74570

9130423L19Rik

2.11

1.5

   

C85657

 

C85657

2.11

    

RIKEN cDNA 5730493B19 gene

 

5730493B19Rik

2.10

    

Fucosyltransferase 9

14348

Fut9

2.10

4.0

3.15

  

AU022045

 

AU022045

2.07

    

Jagged 1

16449

Jag1

2.06

1.5

1.20

RV, CB, SB,PT

[82]

EH-domain containing 2

259300

Ehd2

2.02

 

0.00

  

RIKEN cDNA 2610510D13 gene

229279

2610510D13Rik

2.01

-0.5

   
  1. Abbreviations: CB, comma-shaped body; CT, collecting tubule; DN, developing nephron; DG, developing glomerulus; DT: distal convoluted tubule; Gl: glomerulus; HL, loop of Henle; PT, proximal convoluted tubule; Pod, podocyte; RT, renal tubule; RV: renal vesicle; SB, S-shaped body; UD, ureteric duct; UT, ureteric tubule