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Table 10 Differences in immunohistochemical findings between MPO-ANCA (+) and PR3-ANCA (+) patients

From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)

  MPO-ANCA (+) N = 17 PR3-ANCA (+) N = 9 p
I. Glomeruli    
PCNA(+) cells 28 ± 14 47 ± 12 NS
α-SMA(+)cells 36 ± 12 32 ± 23 NS
Monocytes/macrophages 17 ± 12 12 ± 3 NS
LFA-1β(+)cells 14 ± 5 21 ± 8 NS
TGF-β1 expression 1.0 ± 0.7 1.5 ± 0.7 NS
ICAM-1 expression 1.5 ± 0.67 1.66 ± 0.58 NS
C5b-9 expression 2.2 ± 1.08 2.5 ± 0.58 NS
II. Tubulointerstitium    
HLA-DR(+) cells 1293 ± 894 866 ± 467 NS
PCNA(+)cells 757 ± 166 947 ± 92 0.041
α-SMA(+)cells 702 ± 222 779 ± 348 NS
Monocytes/macrophages 550 ± 181 614 ± 264 NS
LFA-1β(+)cells 469 ± 157 552 ± 106 NS
ICAM-1 in tubules 35.4 ± 10.8 29.4 ± 15 NS
C5b-9 in tubules 30.6 ± 9,4 37.3 ± 10.2 NS
TGF-β1 in interstitium 1.45 ± 0.7 2.67 ± 0.6 0.017
TGF-β1 in tubules 1.67 ± 0.78 2.25 ± 0.96 NS
ICAM-1in vessels 1,18 ± 0,4 1.3 ± 0.57 NS
C5b-9 in vessels 1.08 ± 0.29 1.0 ± 0.07 NS