Table 10 Differences in immunohistochemical findings between MPO-ANCA (+) and PR3-ANCA (+) patients
From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)
MPO-ANCA (+) N = 17 | PR3-ANCA (+) N = 9 | p | |
|---|---|---|---|
I. Glomeruli | |||
PCNA(+) cells | 28 ± 14 | 47 ± 12 | NS |
α-SMA(+)cells | 36 ± 12 | 32 ± 23 | NS |
Monocytes/macrophages | 17 ± 12 | 12 ± 3 | NS |
LFA-1β(+)cells | 14 ± 5 | 21 ± 8 | NS |
TGF-β1 expression | 1.0 ± 0.7 | 1.5 ± 0.7 | NS |
ICAM-1 expression | 1.5 ± 0.67 | 1.66 ± 0.58 | NS |
C5b-9 expression | 2.2 ± 1.08 | 2.5 ± 0.58 | NS |
II. Tubulointerstitium | |||
HLA-DR(+) cells | 1293 ± 894 | 866 ± 467 | NS |
PCNA(+)cells | 757 ± 166 | 947 ± 92 | 0.041 |
α-SMA(+)cells | 702 ± 222 | 779 ± 348 | NS |
Monocytes/macrophages | 550 ± 181 | 614 ± 264 | NS |
LFA-1β(+)cells | 469 ± 157 | 552 ± 106 | NS |
ICAM-1 in tubules | 35.4 ± 10.8 | 29.4 ± 15 | NS |
C5b-9 in tubules | 30.6 ± 9,4 | 37.3 ± 10.2 | NS |
TGF-β1 in interstitium | 1.45 ± 0.7 | 2.67 ± 0.6 | 0.017 |
TGF-β1 in tubules | 1.67 ± 0.78 | 2.25 ± 0.96 | NS |
ICAM-1in vessels | 1,18 ± 0,4 | 1.3 ± 0.57 | NS |
C5b-9 in vessels | 1.08 ± 0.29 | 1.0 ± 0.07 | NS |