Table 4 Clinical and histologic data at presentation
From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)
Responders N = 24 | Non responders N = 10 | p | |
|---|---|---|---|
I. Clinical | |||
Age (years) | 58 ± 16 | 44 ± 19 | 0.036 |
pCreatinine at biopsy (mg/dl) | 4.8 ± 2.6 | 10.2 ± 5.8 | 0.001 |
pUrea at biopsy (mg/dl) | 105.2 ± 29.8 | 184 ± 97.5 | 0.001 |
CRP (mg/l) | 44 ± 49 | 143 ± 92 | <0.0001 |
ESR (mm/1 h) | 112 ± 28 | 118 ± 47 | NS |
24 h urinary albumin excretion (g) | 1.26 ± 1.1 | 1.66 ± 0.64 | NS |
II. Histologic | |||
Crescents (%) | 65 ± 32 | 47 ± 32 | NS |
Cellular crescents | 64 ± 43 | 49 ± 53 | NS |
Fibrocellular crescents | 8 ± 20 | 38 ± 52 | 0.027 |
Fibrous crescents | 12 ± 24 | 11 ± 2 | NS |
Obsolete glomeruli | 27 ± 20 | 29 ± 27 | NS |
Focal necrosis | 1.33 ± 0.48 | 1.60 ± 0.52 | NS |
TIN infiltration | 1.19 ± 1.03 | 1.22 ± 0.97 | NS |
Tubular atrophy | 0.95 ± 0.72 | 1.89 ± 1.16 | 0.011 |
TIN fibrosis | 1.2 ± 0.99 | 2.22 ± 0.97 | 0.002 |
Arterial sclerosis | 1.40 ± 1.07 | 1.67 ± 1.12 | 0.05 |