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Table 5 Immunohistological findings at presentation

From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)

  Responders N = 24 Non responders N = 10 p
I. Glomeruli    
PCNA(+) cells 38 ± 16 31 ± 16 NS
α-SMA(+)cells 30 ± 16 38 ± 17 NS
Monocytes/macrophages 16 ± 11 15 ± 8 NS
LFA-1β(+)cells 14 ± 5 22 ± 8 NS
TGF-β1 expression 1.0 ± 0.63 2.2 ± 0.84 0.046
ICAM-1 expression 1.67 ± 0.78 1.71 ± 0.75 NS
C5b-9 expression 2.14 ± 0.95 2.6 ± 0.54 NS
II. Tubulointerstitium    
HLA-DR(+) cells 986 ± 702 1484 ± 1022 NS
PCNA(+)cells 845 ± 145 686 ± 160 NS
α-SMA(+)cells 732 ± 275 497 ± 224 NS
Monocytes/macrophages 580 ± 222 473 ± 144 NS
LFA-1β(+)cells 512 ± 151 460 ± 132 NS
ICAM-1 in tubules 29.3 ± 9.5 48.8 ± 4.9 <0.0001
C5b-9 in tubules 29.6 ± 8.5 38.9 ± 9.1 0.05
TGF-β1 in interstitium 1.57 ± 0.94 2.4 ± 0.55 NS
TGF-β1 in tubules 1.78 ± 0.80 2.4 ± 0.89 NS
ICAM-1in vessels 1.27 ± 0.46 1.10 ± 0.01 NS
C5b-9 in vessels 1.06 ± 0.26 1.01 ± 0.09 NS