Table 5 Immunohistological findings at presentation
From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)
Responders N = 24 | Non responders N = 10 | p | |
|---|---|---|---|
I. Glomeruli | |||
PCNA(+) cells | 38 ± 16 | 31 ± 16 | NS |
α-SMA(+)cells | 30 ± 16 | 38 ± 17 | NS |
Monocytes/macrophages | 16 ± 11 | 15 ± 8 | NS |
LFA-1β(+)cells | 14 ± 5 | 22 ± 8 | NS |
TGF-β1 expression | 1.0 ± 0.63 | 2.2 ± 0.84 | 0.046 |
ICAM-1 expression | 1.67 ± 0.78 | 1.71 ± 0.75 | NS |
C5b-9 expression | 2.14 ± 0.95 | 2.6 ± 0.54 | NS |
II. Tubulointerstitium | |||
HLA-DR(+) cells | 986 ± 702 | 1484 ± 1022 | NS |
PCNA(+)cells | 845 ± 145 | 686 ± 160 | NS |
α-SMA(+)cells | 732 ± 275 | 497 ± 224 | NS |
Monocytes/macrophages | 580 ± 222 | 473 ± 144 | NS |
LFA-1β(+)cells | 512 ± 151 | 460 ± 132 | NS |
ICAM-1 in tubules | 29.3 ± 9.5 | 48.8 ± 4.9 | <0.0001 |
C5b-9 in tubules | 29.6 ± 8.5 | 38.9 ± 9.1 | 0.05 |
TGF-β1 in interstitium | 1.57 ± 0.94 | 2.4 ± 0.55 | NS |
TGF-β1 in tubules | 1.78 ± 0.80 | 2.4 ± 0.89 | NS |
ICAM-1in vessels | 1.27 ± 0.46 | 1.10 ± 0.01 | NS |
C5b-9 in vessels | 1.06 ± 0.26 | 1.01 ± 0.09 | NS |