Table 7 Clinical and histologic differences between ANCA (+) and ANCA (-) patients
From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)
ANCA (+) N = 26 | ANCA (-) N = 8 | p | |
|---|---|---|---|
I. Clinical | |||
Age (years) | 60 ± 13 | 42 ± 20 | 0,005 |
pCreatinine at biopsy (mg/dl) | 6.11 ± 4.7 | 5.7 ± 1.8 | NS |
pUrea at biopsy (mg/dl) | 128.3 ± 69.3 | 109.4 ± 25.5 | NS |
CRP (mg/l) | 64.7 ± 75 | 99 ± 86 | NS |
ESR (mm/1 h) | 116 ± 28 | 108 ± 44 | NS |
24 h urinary albumin excretion (g) | 2.21 ± 1.12 | 1.17 ± 0.77 | 0,005 |
II. Histologic | |||
Crescents (%) | 63 ± 33 | 52 ± 32 | NS |
Cellular crescents | 59 ± 44 | 51 ± 47 | NS |
Fibrocellular crescents | 11 ± 26 | 51 ± 47 | NS(0.06) |
Fibrous crescents | 12 ± 24 | 11 ± 21 | NS |
Obsolete glomeruli | 25 ± 23 | 35 ± 19 | NS |
Focal necrosis | 1.34 ± 0.48 | 1.62 ± 0.52 | NS |
TIN infiltration | 1.36 ± 1.13 | 1.87 ± 0.99 | NS |
Tubular atrophy | 1.13 ± 0.97 | 1.5 ± 0.93 | NS |
TIN fibrosis | 1.4 ± 1.1 | 1.59 ± 0.5 | NS |
Arterial sclerosis | 1.79 ± 1.06 | 2.25 ± 0.96 | 0.05 |