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Table 7 Clinical and histologic differences between ANCA (+) and ANCA (-) patients

From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)

  ANCA (+) N = 26 ANCA (-) N = 8 p
I. Clinical    
Age (years) 60 ± 13 42 ± 20 0,005
pCreatinine at biopsy (mg/dl) 6.11 ± 4.7 5.7 ± 1.8 NS
pUrea at biopsy (mg/dl) 128.3 ± 69.3 109.4 ± 25.5 NS
CRP (mg/l) 64.7 ± 75 99 ± 86 NS
ESR (mm/1 h) 116 ± 28 108 ± 44 NS
24 h urinary albumin excretion (g) 2.21 ± 1.12 1.17 ± 0.77 0,005
II. Histologic    
Crescents (%) 63 ± 33 52 ± 32 NS
Cellular crescents 59 ± 44 51 ± 47 NS
Fibrocellular crescents 11 ± 26 51 ± 47 NS(0.06)
Fibrous crescents 12 ± 24 11 ± 21 NS
Obsolete glomeruli 25 ± 23 35 ± 19 NS
Focal necrosis 1.34 ± 0.48 1.62 ± 0.52 NS
TIN infiltration 1.36 ± 1.13 1.87 ± 0.99 NS
Tubular atrophy 1.13 ± 0.97 1.5 ± 0.93 NS
TIN fibrosis 1.4 ± 1.1 1.59 ± 0.5 NS
Arterial sclerosis 1.79 ± 1.06 2.25 ± 0.96 0.05
  1. Abbrev: CRP, C-reactive protein, ESR, erythrocyte sedimentation rate, TIN, tubulointerstitial