Table 9 Clinical and histologic differences between MPO-ANCA (+) and PR3-ANCA (+) patients
From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)
MPO-ANCA (+) N = 17 | PR3-ANCA (+) N = 9 | p | |
|---|---|---|---|
I. Clinical | |||
Age (years) | 63 ± 10 | 55 ± 17 | NS |
pCreatinine at biopsy (mg/dl) | 5.9 ± 4.5 | 6.5 ± 5.3 | NS |
pUrea at biopsy (mg/dl) | 123 ± 56 | 138 ± 92 | NS |
CRP (mg/l) | 54 ± 63 | 84 ± 95 | NS |
ESR (mm/1 h) | 116 ± 34 | 116 ± 16 | NS |
24 h urinary albumin excretion (g) | 1.24 ± 0.81 | 1.04 ± 0.73 | NS |
II. Histologic | |||
Crescents (%) | 61 ± 35 | 67 ± 28 | NS |
Cellular crescents | 56 ± 44 | 66 ± 46 | NS |
Fibrocellular crescents | 13 ± 30 | 8 ± 17 | NS |
Fibrous crescents | 10 ± 21 | 15 ± 31 | NS |
Obsolete glomeruli | 28 ± 22 | 20 ± 24 | NS |
Focal necrosis | 1.41 ± 0.5 | 1.22 ± 0.44 | NS |
TIN infiltration | 1.53 ± 1.12 | 1.0 ± 1.15 | NS |
Tubular atrophy | 1.4 ± 0.98 | 0.62 ± 0.74 | NS |
TIN fibrosis | 1.5 ± 1.09 | 1.07 ± 1.09 | NS |
Arterial sclerosis | 1.94 ± 1.0 | 1.5 ± 1.19 | NS |