Skip to main content

Table 9 Clinical and histologic differences between MPO-ANCA (+) and PR3-ANCA (+) patients

From: Predictors of outcome in idiopathic rapidly progressive glomerulonephritis (IRPGN)

  MPO-ANCA (+) N = 17 PR3-ANCA (+) N = 9 p
I. Clinical    
Age (years) 63 ± 10 55 ± 17 NS
pCreatinine at biopsy (mg/dl) 5.9 ± 4.5 6.5 ± 5.3 NS
pUrea at biopsy (mg/dl) 123 ± 56 138 ± 92 NS
CRP (mg/l) 54 ± 63 84 ± 95 NS
ESR (mm/1 h) 116 ± 34 116 ± 16 NS
24 h urinary albumin excretion (g) 1.24 ± 0.81 1.04 ± 0.73 NS
II. Histologic    
Crescents (%) 61 ± 35 67 ± 28 NS
Cellular crescents 56 ± 44 66 ± 46 NS
Fibrocellular crescents 13 ± 30 8 ± 17 NS
Fibrous crescents 10 ± 21 15 ± 31 NS
Obsolete glomeruli 28 ± 22 20 ± 24 NS
Focal necrosis 1.41 ± 0.5 1.22 ± 0.44 NS
TIN infiltration 1.53 ± 1.12 1.0 ± 1.15 NS
Tubular atrophy 1.4 ± 0.98 0.62 ± 0.74 NS
TIN fibrosis 1.5 ± 1.09 1.07 ± 1.09 NS
Arterial sclerosis 1.94 ± 1.0 1.5 ± 1.19 NS
  1. Abbrev: CRP, C-reactive protein, ESR, erythrocyte sedimentation rate, TIN, tubulointerstitial